Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85721, USA.
Cancer Cell. 2018 Jul 9;34(1):21-43. doi: 10.1016/j.ccell.2018.03.022. Epub 2018 May 3.
The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.
转录因子 NRF2 是细胞抗氧化反应的主要调节因子。虽然最初它被认为是化学预防化合物的靶标，这些化合物有助于预防癌症和其他疾病，但越来越多的证据表明 NRF2 途径是癌症进展、转移和治疗耐药性的驱动因素。最近的研究已经确定了 NRF2 在调节代谢和其他重要细胞功能中的新功能，将 NRF2 确立为一种真正的多效转录因子。在这篇综述中，我们探讨了 NRF2 在癌症特征中的作用，表明了其具有肿瘤抑制和促进肿瘤生长的双重作用。
