Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210029, P.R. China.
The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China.
Biosci Rep. 2019 May 7;39(5). doi: 10.1042/BSR20181743. Print 2019 May 31.
ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. The pathological processes and molecular pathways regulated by CerS-2 were also summarized.
神经酰胺合酶 2（CerS-2）在抑制肿瘤细胞的侵袭和转移中发挥重要作用，并且已被报道为多种癌症中的肿瘤转移抑制基因。因此，CerS-2 蛋白水平较低可能提示预后不良，上调 CerS-2 蛋白可能成为恶性肿瘤有前途的治疗策略。在这篇综述中，我们讨论了 CerS-2 在多种人类癌症中的表达以及临床和病理意义。还总结了 CerS-2 调节的病理过程和分子途径。
