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Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18-55 years of age.在 18-55 岁健康成年人中,比较两种剂量的研究用乙型肝炎病毒表面抗原与免疫刺激性硫代磷酸寡脱氧核苷酸联合使用,以及三种剂量的已上市乙型肝炎疫苗的安全性和免疫原性。
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本文引用的文献

1
Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection.综述文章:乙型肝炎核心相关抗原(HBcrAg):慢性乙型肝炎病毒感染的新兴标志物。
Aliment Pharmacol Ther. 2018 Jan;47(1):43-54. doi: 10.1111/apt.14376. Epub 2017 Oct 16.
2
Relationship between serum HBV-RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients.恩替卡韦治疗患者血清HBV-RNA水平与肝内病毒及组织学活性标志物之间的关系
J Hepatol. 2017 Sep 21. doi: 10.1016/j.jhep.2017.08.021.
3
What is new on HBsAg and other diagnostic markers in HBV infection?乙肝表面抗原及其他乙肝病毒感染诊断标志物有哪些新进展?
Best Pract Res Clin Gastroenterol. 2017 Jun;31(3):281-289. doi: 10.1016/j.bpg.2017.04.009. Epub 2017 May 4.
4
Hepatitis B cure: From discovery to regulatory approval.乙肝治愈:从发现到监管批准。
Hepatology. 2017 Oct;66(4):1296-1313. doi: 10.1002/hep.29323. Epub 2017 Aug 1.
5
New Direct-Acting Antiviral Agents and Immunomodulators for Hepatitis B Virus Infection.用于乙型肝炎病毒感染的新型直接抗病毒药物和免疫调节剂
Gastroenterol Hepatol (N Y). 2017 Jun;13(6):348-356.
6
Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application.完整和不完整的乙型肝炎病毒颗粒:形成、功能及应用
Viruses. 2017 Mar 21;9(3):56. doi: 10.3390/v9030056.
7
The role of quantitative hepatitis B surface antigen revisited.重新探讨定量乙型肝炎表面抗原的作用。
J Hepatol. 2017 Feb;66(2):398-411. doi: 10.1016/j.jhep.2016.08.009. Epub 2016 Aug 27.
8
Serum viral duplex-linear DNA proportion increases with the progression of liver disease in patients infected with HBV.血清病毒双链线性 DNA 比例随着 HBV 感染患者肝病的进展而增加。
Gut. 2016 Mar;65(3):502-11. doi: 10.1136/gutjnl-2014-308989. Epub 2015 Jun 4.
9
Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors.血清乙型肝炎病毒 RNA 水平作为治疗期间乙型肝炎表面抗原血清学转换的早期预测指标。
Hepatology. 2015 Jan;61(1):66-76. doi: 10.1002/hep.27381. Epub 2014 Nov 25.
10
Genotypes and genetic variability of hepatitis B virus.乙型肝炎病毒的基因型与遗传变异性
Intervirology. 2014;57(3-4):141-50. doi: 10.1159/000360947. Epub 2014 Jul 15.

Diagnostics of Hepatitis B Virus: Standard of Care and Investigational.

作者信息

Jackson Kathy, Locarnini Stephen, Gish Robert

机构信息

Victorian Infectious Diseases Reference Laboratory Doherty Institute Melbourne Victoria Australia.

Stanford University, Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center Stanford CA.

出版信息

Clin Liver Dis (Hoboken). 2018 Aug 22;12(1):5-11. doi: 10.1002/cld.729. eCollection 2018 Jul.

DOI:10.1002/cld.729
PMID:30988902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6385904/
Abstract
摘要