Liu Qi, Mazhar Momina, Miller Lloyd S
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Curr Dermatol Rep. 2018 Dec;7(4):338-349. doi: 10.1007/s13671-018-0235-8. Epub 2018 Sep 22.
There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, (). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to skin infections.
Antimicrobial peptides, pattern recognition receptors and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against skin infections. In addition, certain mechanisms by which contributes to aberrant cutaneous inflammation, such as in flares of the inflammatory skin disease atopic dermatitis have also been identified.
These cutaneous immune mechanisms could provide new targets for future vaccines and immune-based therapies to combat skin infections and cutaneous inflammation caused by .
近期，我们对人类重要皮肤病原体（）的皮肤免疫反应有了新的认识。本综述将重点介绍这些关于宿主防御中固有免疫和适应性免疫机制以及皮肤感染引发的皮肤炎症的见解。
抗菌肽、模式识别受体和炎性小体激活在固有免疫中发挥作用，而T细胞及其效应细胞因子在针对皮肤感染的适应性免疫中起关键作用。此外，还确定了（病原体）导致皮肤异常炎症的某些机制，例如炎症性皮肤病特应性皮炎的发作。
这些皮肤免疫机制可为未来疫苗和基于免疫的疗法提供新靶点，以对抗由（病原体）引起的皮肤感染和皮肤炎症。
