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新型铋银纳米颗粒合成物对[具体感染模型1]和[具体感染模型2]感染模型的抗菌效果

Antibacterial efficacy of novel bismuth-silver nanoparticles synthesis on and infection models.

作者信息

Castro-Valenzuela Beatriz Elena, Franco-Molina Moisés Armides, Zárate-Triviño Diana Ginette, Villarreal-Treviño Licet, Kawas Jorge R, García-Coronado Paola Leonor, Sobrevilla-Hernández Gustavo, Rodríguez-Padilla Cristina

机构信息

Laboratorio de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, Mexico.

Posgrado en Microbiología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, Mexico.

出版信息

Front Microbiol. 2024 Apr 8;15:1376669. doi: 10.3389/fmicb.2024.1376669. eCollection 2024.

DOI:10.3389/fmicb.2024.1376669
PMID:38650875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11033500/
Abstract

INTRODUCTION

The emergence of multi-drug-resistant bacteria is one of the main concerns in the health sector worldwide. The conventional strategies for treatment and prophylaxis against microbial infections include the use of antibiotics. However, these drugs are failing due to the increasing antimicrobial resistance. The unavailability of effective antibiotics highlights the need to discover effective alternatives to combat bacterial infections. One option is the use of metallic nanoparticles, which are toxic to some microorganisms due to their nanometric size.

METHODS

In this study we (1) synthesize and characterize bismuth and silver nanoparticles, (2) evaluate the antibacterial activity of NPs against and in several infection models ( models: infected wound and sepsis and model: mastitis), and we (3) determine the cytotoxic effect on several cell lines representative of the skin tissue.

RESULTS AND DISCUSSION

We obtained bimetallic nanoparticles of bismuth and silver in a stable aqueous solution from a single reaction by chemical synthesis. These nanoparticles show antibacterial activity on and without cytotoxic effects on fibroblast, endothelial vascular, and mammary epithelium cell lines. In an infected-wound mice model, antibacterial effect was observed, without effect on mastitis and sepsis models.

摘要

引言

多重耐药菌的出现是全球卫生领域主要关注的问题之一。治疗和预防微生物感染的传统策略包括使用抗生素。然而，由于日益增加的抗菌耐药性，这些药物正逐渐失效。有效抗生素的缺乏凸显了发现对抗细菌感染的有效替代方法的必要性。一种选择是使用金属纳米颗粒，由于其纳米尺寸，它们对某些微生物有毒性。

方法

在本研究中，我们（1）合成并表征铋和银纳米颗粒，（2）在几种感染模型（感染伤口和败血症模型： ；乳腺炎模型： ）中评估纳米颗粒对 和 的抗菌活性，并且我们（3）确定对几种代表皮肤组织的细胞系的细胞毒性作用。

结果与讨论

通过化学合成从单一反应中在稳定的水溶液中获得了铋和银的双金属纳米颗粒。这些纳米颗粒对 和 显示出抗菌活性，而对成纤维细胞、血管内皮细胞和乳腺上皮细胞系没有细胞毒性作用。在感染伤口小鼠模型中观察到了抗菌效果，而对乳腺炎和败血症模型没有影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/11033500/98bb236f0cc6/fmicb-15-1376669-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/11033500/304cd1a07723/fmicb-15-1376669-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a4/11033500/98bb236f0cc6/fmicb-15-1376669-g012.jpg

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