Abdel-Kader Mohamed Ahmed, Abdelazeem Ahmad Farouk, Ahmed Nermeen El-Moataz Bellah, Khalil Yasmin Mohamed, Mostafa Mostafa Ibrahim
Department of Oro-dental Genetics, Medical Research Centre of Excellency, National Research Centre, Cairo, Egypt.
Prosthodontic Department, Faculty of Dentistry, Misr International University, Cairo, Egypt.
Spec Care Dentist. 2019 May;39(3):330-339. doi: 10.1111/scd.12378. Epub 2019 Apr 16.
to investigate for the first time whether the regenerative approach can be used to rehabilitate a case with regional odontodysplasia (ROD). ROD is a rare, localized developmental anomaly of the dental tissues. Moreover, we review the various treatment protocols for ROD and compare them to the suggested regenerative protocol.
A 22-year-old female patient diagnosed with ROD in the upper left quadrant was presented to our clinic. Initially, the affected teeth were extracted and three implants were inserted. A combination of autologous bone marrow mononuclear cells (BMMNCs) seeded on a collagen sponge, nanohydroxyapatite, and autologous platelet-rich fibrin (PRF) was used to enhance bone regeneration in the defective area and around the inserted implants. After 9 months, bone regeneration and successful osteointegration around the inserted implants were achieved, permitting the insertion of a fourth implant. After an additional six months, a final fixed restoration was constructed.
The suggested regenerative approach provides a better treatment option for ROD patients to regenerate the lost bone, rehabilitate aesthetics, and restore normal function.
首次研究再生方法是否可用于修复一例局部牙发育异常（ROD）病例。ROD是一种罕见的、局限于局部的牙组织发育异常。此外，我们回顾了ROD的各种治疗方案，并将它们与建议的再生方案进行比较。
一名22岁女性患者，左上象限被诊断为ROD，前来我们诊所就诊。最初，拔除了患牙并植入了三颗种植体。将自体骨髓单个核细胞（BMMNCs）接种在胶原海绵、纳米羟基磷灰石和自体富血小板纤维蛋白（PRF）上的组合，用于增强缺损区域和植入种植体周围的骨再生。9个月后，植入种植体周围实现了骨再生和成功的骨整合，从而能够植入第四颗种植体。再过6个月后，制作了最终的固定修复体。
建议的再生方法为ROD患者提供了更好的治疗选择，以再生缺失的骨组织、恢复美观并恢复正常功能。
