Liu Yi-Fei, Hu Zhi-Gang, Xu Jiang, Chen Shi-Lin
College of Pharmacy,Hubei University of Chinese Medicine Wuhan 430065,China.
Institute of Chinese Materia Medica,Chinese Academy of Chinese Medical Science Beijing 100700,China.
Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(5):891-898. doi: 10.19540/j.cnki.cjcmm.20181226.021.
China is rich in the diversified Chinese medicine resources and is notable for the wide and long-term applications of Chinese medicine. However,the lack of genomic information on medicinal taxa leads to problems in relation to resource conservation and the downstream application of traditional Chinese medicine resources,which restricts the modernization process of traditional Chinese medicine. Molecular phylogenetics is an important tool to understand the origin and evolution of the earth's biodiversity and promote the conservation and use of medicinal taxa. With the development of sequencing technology,the combination of genomic data extends the traditional molecular phylogenetics to the research level of phylogenomics,making it more powerfully applied to all aspects of biological research. Undoubtedly,carrying out phylogenomic research on Chinese medicine species will greatly promote their resources conservation,molecular evaluation and identification,and the exploration and utilization of natural pharmacodynamic components,promoting the modernization of traditional Chinese medicine. This article starts with a brief introduction of the developing history and basic research methods of phylogenomics,and then reviews the current research progress in phylogenomics related to traditional Chinese medicine resources. Finally,it discusses the problems existing in the current research and the next direction of phylogenomics research in medicinal taxa. The article will hopefully provide a reference for relevant researches in future.
中国拥有丰富多样的中药资源,且以中药广泛且长期的应用而闻名。然而,药用类群基因组信息的缺乏导致了中药资源保护及下游应用方面的问题,这限制了中药现代化进程。分子系统发育学是了解地球生物多样性起源与演化、促进药用类群保护与利用的重要工具。随着测序技术的发展,基因组数据的结合将传统分子系统发育学扩展到了系统发育基因组学的研究层面,使其更有力地应用于生物学研究的各个方面。毫无疑问,开展中药物种的系统发育基因组学研究将极大地促进其资源保护、分子评价与鉴定以及天然药效成分的探索与利用,推动中药现代化。本文首先简要介绍系统发育基因组学的发展历程和基础研究方法,然后综述与中药资源相关的系统发育基因组学研究现状。最后,讨论当前研究中存在的问题以及药用类群系统发育基因组学研究的未来方向。希望本文能为今后的相关研究提供参考。