a Division of Molecular Biology, Institute Potosino of Scientific and Technological Research , San Luis Potosí , México.
Biomarkers. 2019 Sep;24(6):499-509. doi: 10.1080/1354750X.2019.1606279. Epub 2019 Jun 11.
Differential expression profiles of microRNAs have been reported in human obesity suggesting a miRNAs role in the development of obesity and associated disorders. To review circulating microRNAs (c-miRNAs) dysregulated in human obesity and to predict their possible target genes. We performed a systematic review on PubMed database (PROSPERO, CRD42017077742) for original works on c-miRNAs and human obesity and recorded c-miRNAs with differential expression profiles. Potential target genes and metabolic pathways for dysregulated miRNAs with at least two independent reports were searched using bioinformatic tools. Twenty-two c-miRNAs are overexpressed, nine underexpressed and two c-miRNAs dysregulated in both directions in people with obesity compared to lean controls. Bioinformatic analyses suggest these c-miRNAs target on genes associated with fatty acid metabolism and PI3k/Akt pathway. Literature records 33 c-miRNAs confirmedly dysregulated in human obesity. Their predicted target genes are involved in pathways that could explain the development of obesity and its comorbidities. Further research will clarify the role of these miRNAs on metabolic diseases and their usefulness for the prognosis, prevention and treatment of obesity.
已有研究报道，在人类肥胖症中存在 microRNA（miRNA）的差异表达谱，提示 miRNA 在肥胖症及其相关疾病的发生发展中具有一定作用。本文旨在综述人类肥胖症中循环 microRNA（c-miRNA）的失调情况，并预测其可能的靶基因。
我们在 PubMed 数据库（PROSPERO，CRD42017077742）上进行了一项关于 c-miRNA 和人类肥胖症的原始研究的系统综述，并记录了具有差异表达谱的 c-miRNA。使用生物信息学工具，针对至少有两份独立报道的失调 miRNA 进行潜在靶基因和代谢途径搜索。与瘦对照组相比，肥胖人群中存在 22 个 miRNA 高表达、9 个 miRNA 低表达以及 2 个 miRNA 双向失调。生物信息学分析提示这些 c-miRNA 靶向与脂肪酸代谢和 PI3k/Akt 通路相关的基因。文献中记录了 33 种在人类肥胖症中被证实失调的 c-miRNA。它们预测的靶基因参与了可以解释肥胖症及其合并症发生发展的通路。进一步的研究将阐明这些 miRNA 在代谢性疾病中的作用及其在肥胖症的预后、预防和治疗中的应用价值。
