协同亲核芳香取代反应

Rohrbach Simon, Smith Andrew J, Pang Jia Hao, Poole Darren L, Tuttle Tell, Chiba Shunsuke, Murphy John A

Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.

Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16368-16388. doi: 10.1002/anie.201902216. Epub 2019 Sep 13.

Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS Ar) rather than classical, two-step, S Ar mechanisms. Whereas traditional S Ar reactions require substantial activation of the aromatic ring by electron-withdrawing substituents, such activating groups are not mandatory in the concerted pathways.

实验化学和计算化学方面的最新进展已经确定了一类快速发展的亲核芳香取代反应，这些反应是通过协同（cS Ar）而非经典的两步S Ar机制进行的。传统的S Ar反应需要吸电子取代基对芳香环进行大量活化，而在协同反应途径中，此类活化基团并非必需。