Yu Lu, Somfai Peter
Centre for Analysis and Synthesis, Department of Chemistry, Lund University, 22100, Lund, Sweden.
Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8551-8555. doi: 10.1002/anie.201902642. Epub 2019 May 10.
The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.
报道了使用氢化铜催化剂对烯胺进行不对称形式的氢胺化反应。该方法为合成手性1,2 - 二烷基胺提供了一种直接且高效的途径，对于多种底物都能以良好的产率和高对映选择性得到产物，并且对于制备含有1,2 - 二胺基序的分子具有重要价值。
