基于网络药理学的研究探讨加味四君子汤对慢性萎缩性胃炎各亚型的作用机制。

Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis.

机构信息

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.

Beijing University of Chinese Medicine, Beijing, 100029, China; The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, 266071, China.

出版信息

Pharmacol Res. 2019 Jun;144:158-166. doi: 10.1016/j.phrs.2019.04.012. Epub 2019 Apr 13.

DOI:10.1016/j.phrs.2019.04.012

PMID:30991106

Abstract

Chronic atrophic gastritis (CAG) is a common digestive disease without specific treatment. According to syndrome differentiation, traditional Chinese medicine (TCM) classified it into different syndromes and has achieved significant therapeutic effects. In this study, immune repertoire sequencing techniques combined with symptom scores, electronic gastroscopy as well as pathologic changes were used to evaluate the effect and the underlying mechanism of Modified Sijunzi Decoction (MSD) in treating CAG. The results showed that MSD could relieve CAG symptoms, improve pathologic changes in CAG with fatigue and tiredness symptom, but with no help in CAG with reversal heat symptom. Moreover, MSD could regulate immune disorders in CAG with fatigue and tiredness symptom, and 7 TCR biomarkers were explored in CAG patients with immune disorders. All these results indicated that MSD is effective in treating CAG patients with fatigue and tiredness symptom by tonifying the spleen qi, suggesting that CAG treatment based on syndrome differentiation is reasonable.

摘要

慢性萎缩性胃炎（CAG）是一种常见的消化系统疾病，目前尚无特效疗法。根据中医辨证论治理论，CAG 可分为不同证型，中医药治疗 CAG 具有确切疗效。本研究采用免疫组库测序技术结合症状评分、电子胃镜及病理改变，评价加味四君子汤治疗 CAG 的疗效及作用机制。结果表明，加味四君子汤可改善 CAG 患者的临床症状，减轻 CAG 患者疲劳乏力症状的病理改变，但对 CAG 患者的逆转热症状无明显帮助。同时，加味四君子汤可调节 CAG 患者的免疫紊乱，探索到 7 个与 CAG 患者免疫紊乱相关的 TCR 生物标志物。这些结果提示加味四君子汤通过健脾益气治疗 CAG 患者的疲劳乏力症状是有效的，表明中医辨证论治治疗 CAG 具有合理性。