Russo Tiziana, Currò Monica, Ferlazzo Nadia, Caccamo Daniela, Perrone Patrizia, Arena Salvatore, Antonelli Enrica, Antonuccio Pietro, Ientile Riccardo, Romeo Carmelo, Impellizzeri Pietro
Department of Human Pathology of Adult and Childhood "Gaetano Barresi", Pediatric Surgery Unit- University of Messina, Messina, Italy.
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Urol Int. 2019;103(4):459-465. doi: 10.1159/000499846. Epub 2019 Apr 16.
Lichen sclerosus (LS) is a disease of the skin of unclear etiology that can occur in the foreskin. Topical therapy with corticosteroids is recommended, but they can have side effects.
We aimed to compare the effects of ozonides with vitamin E acetate (OZOILE) versus topical corticosteroid in children undergoing circumcision.
Twenty children undergoing circumcision were treated before surgery: 10 children with OZOILE cream and 10 with 0.1% mometasone furoate once a day for 7 days. Ten age-matched patients with LS of the foreskin without any treatment were recruited as controls. Transcript levels of proinflammatory and anti-inflammatory cytokines and e-cadherin were evaluated in removed foreskins by qRT-PCR.
OZOILE and steroid topical treatment produced a similar reduction of TNF-α and IL-1β mRNA levels in foreskins from patients with LS when compared to untreated patients (p < 0.001). OZOILE and steroid treatment caused an increase in the transcript levels of IL-13 and e-cadherin in the foreskin of patients affected by LS in comparison to untreated foreskin (p < 0.001).
On the basis of our biochemical data, a randomized clinical trial might be useful to verify the actual clinical effect of OZOILE as alternative treatment to corticosteroids in children affected by LS of the foreskin.
硬化性苔藓（LS）是一种病因不明的皮肤疾病，可发生于包皮。推荐使用皮质类固醇进行局部治疗，但它们可能有副作用。
我们旨在比较环氧化合物与维生素E醋酸酯（OZOILE）和局部皮质类固醇对接受包皮环切术儿童的影响。
20名接受包皮环切术的儿童在手术前接受治疗：10名儿童使用OZOILE乳膏，10名儿童每天使用一次0.1%糠酸莫米松，持续7天。招募10名年龄匹配的未经任何治疗的包皮LS患者作为对照。通过qRT-PCR评估切除包皮中促炎和抗炎细胞因子以及E-钙黏蛋白的转录水平。
与未治疗的患者相比，OZOILE和类固醇局部治疗使LS患者包皮中TNF-α和IL-1β mRNA水平有类似程度的降低（p < 0.001）。与未治疗的包皮相比，OZOILE和类固醇治疗使受LS影响患者的包皮中IL-13和E-钙黏蛋白的转录水平升高（p < 0.001）。
根据我们的生化数据，一项随机临床试验可能有助于验证OZOILE作为受包皮LS影响儿童皮质类固醇替代治疗的实际临床效果。
