Coppola Vincenzo, Escolino Maria, Del Conte Fulvia, Di Mento Claudia, Carraturo Francesca, Esposito Giovanni, Tedesco Francesco, Guglielmini Roberta, Esposito Ciro
Pediatric Surgery Unit, University of Naples Federico II, 80131 Naples, Italy.
CEINGE Advanced Biotechnology Center, 80131 Naples, Italy.
Children (Basel). 2025 Apr 24;12(5):549. doi: 10.3390/children12050549.
Many ozone-based products that promote the healing process of wounds have been released in recent years. In this study, we evaluate a new spray dressing preparation based on stable ozonides with Vitamin E Acetate in children operated for distal hypospadias. : We included all patients with distal hypospadias, who underwent Tubularized Incised Plate Urethroplasty (TIPU) over a 12-month period. The patients were randomized in two groups according to the type of medication: ozonide spray with Vitamin E Acetate (G1); hyaluronic acid cream (G2). After discharge, parents changed the dressing twice a day for 2-3 weeks postoperatively. The patients were evaluated at 7, 14, 21, 30, 60, and 180 postoperative days and thereafter annually. At the end of the treatment, we submitted a satisfaction questionnaire to parents. : Eighty-six patients (median age 18 months) were included. The wound healing was significantly faster in G1 compared with G2 ( = 0.001). No adverse skin reactions occurred in either group. Foreskin dehiscence and re-operation rates were lower in G1. Postoperative foreskin retractability was better in G1, with a significantly higher incidence of secondary phimosis in G2. The median treatment costs were significantly lower in G1 compared with G2 ( = 0.001). Group 1 found the spray dressing easy to use, improving patient management and adherence. : The new preparation of ozonide-based product adopted promoted faster wound healing compared to conventional dressing. Furthermore, this spray preparation is easy to apply, economical, and simpler to preserve. This is better for parents who do not have to touch the wound to apply the product.
近年来，许多促进伤口愈合的臭氧基产品已上市。在本研究中，我们评估了一种基于稳定臭氧化物与维生素E醋酸酯的新型喷雾敷料制剂在接受远端尿道下裂手术的儿童中的应用。我们纳入了所有在12个月期间接受管状切开板尿道成形术（TIPU）的远端尿道下裂患者。根据用药类型将患者随机分为两组：含维生素E醋酸酯的臭氧化物喷雾组（G1）；透明质酸乳膏组（G2）。出院后，家长在术后2 - 3周每天更换敷料两次。在术后第7、14、21、30、60和180天对患者进行评估，此后每年评估一次。治疗结束时，我们向家长提交了一份满意度问卷。共纳入86例患者（中位年龄18个月）。与G2组相比，G1组伤口愈合明显更快（P = 0.001）。两组均未发生不良皮肤反应。G1组的包皮裂开和再次手术率较低。G1组术后包皮可退缩性更好，G2组继发性包茎发生率明显更高。与G2组相比，G1组的中位治疗成本显著更低（P = 0.001）。G1组认为喷雾敷料易于使用，改善了患者管理和依从性。与传统敷料相比，采用的新型臭氧化物基产品制剂促进伤口愈合更快。此外，这种喷雾制剂易于应用、经济且保存更简单。对于不必接触伤口即可应用产品的家长来说更好。
