Christensen Matthew A, Smoak Peter, Lisano Jonathon K, Hayward Reid, Coronado Craig, Kage Katie, Shackelford Daniel, Stewart Laura K
School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO, USA.
University of Northern Colorado Cancer Rehabilitation Institute, Greeley, CO, USA.
Nutr Health. 2019 Sep;25(3):195-202. doi: 10.1177/0260106019841840. Epub 2019 Apr 16.
The control of chronic inflammation has emerged as a target for improving the health of cancer survivors (CS).
To examine differences in fitness and dietary characteristics of CS when grouped by low vs. moderate to high serum C-reactive protein (CRP).
CS ( = 26, mean age = 68 ± 12 years) were evaluated for body mass index (BMI), body composition, cardiorespiratory fitness, dietary intake, dietary inflammatory index (DII), and serum CRP. Participants were assigned to one of two groups based on serum CRP concentrations: low CRP (≤1 mg/L) (LWC; = 13) or moderate to high (CRP > 1 mg/L) (MHC; = 13) and t-tests compared them. Data are presented as mean ± SD.
LWC had higher VOpeak values (mL/kg/min) ( = 0.0003), and lower visceral fat area (cm) ( = 0.02) and body fat mass (kg) ( = 0.04). Secondary analysis using Pearson's correlation coefficients, including all current study participant data, found significant negative relationships between CRP and total dietary fat intake ( = 0.02), saturated fat ( = 0.03), and polyunsaturated fat ( = 0.03).
CS with moderate to high serum CRP concentrations had higher fat mass, visceral fat mass, and lower cardiorespiratory fitness. There was a significant negative relationship between dietary, fat, polyunsaturated and saturated fat, and CRP. However, these dietary fat related findings warrant further investigation. To summarize, improving cardiorespiratory fitness, maintaining lower body fat, may be helpful in altering chronic inflammation in CS.
慢性炎症的控制已成为改善癌症幸存者（CS）健康状况的一个目标。
按血清C反应蛋白（CRP）水平低与中高分组，研究癌症幸存者在体能和饮食特征方面的差异。
对癌症幸存者（n = 26，平均年龄 = 68 ± 12岁）进行体重指数（BMI）、身体成分、心肺功能、饮食摄入量、饮食炎症指数（DII）和血清CRP评估。根据血清CRP浓度将参与者分为两组：低CRP（≤1 mg/L）（LWC；n = 13）或中高（CRP > 1 mg/L）（MHC；n = 13），并采用t检验进行比较。数据以平均值±标准差表示。
低CRP组的峰值摄氧量（mL/kg/min）更高（P = 0.0003），内脏脂肪面积（cm）更低（P = 0.02），身体脂肪量（kg）更低（P = 0.04）。使用皮尔逊相关系数进行的二次分析（包括所有当前研究参与者的数据）发现，CRP与总膳食脂肪摄入量（P = 0.02）、饱和脂肪（P = 0.03）和多不饱和脂肪（P = 0.03）之间存在显著负相关。
血清CRP浓度中高的癌症幸存者有更高的脂肪量、内脏脂肪量和更低的心肺功能。膳食脂肪、多不饱和脂肪和饱和脂肪与CRP之间存在显著负相关。然而，这些与膳食脂肪相关的发现值得进一步研究。总之，改善心肺功能、保持较低的体脂可能有助于改变癌症幸存者的慢性炎症。
