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Fontan-associated liver disease: Monitoring progression of liver fibrosis.Fontan相关肝病：监测肝纤维化进展
Clin Liver Dis (Hoboken). 2018 Jan 31;11(1):1-5. doi: 10.1002/cld.681. eCollection 2018 Jan.
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Non-invasive biomarkers of Fontan-associated liver disease.Fontan相关肝病的非侵入性生物标志物
JHEP Rep. 2021 Sep 14;3(6):100362. doi: 10.1016/j.jhepr.2021.100362. eCollection 2021 Dec.
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Identification of liver fibrosis using the hepatic vein waveform in patients with Fontan circulation.利用肝静脉波形识别Fontan循环患者的肝纤维化
Hepatol Res. 2019 Mar;49(3):304-313. doi: 10.1111/hepr.13248. Epub 2018 Sep 27.
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[Fontan-associated liver disease current status and transplantation consideration].[Fontan相关肝病的现状及移植考量]
Zhonghua Gan Zang Bing Za Zhi. 2023 Jan 20;31(1):109-112. doi: 10.3760/cma.j.cn501113-20210612-00277.
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The Rate of Hepatic Fibrosis Progression in Patients Post-Fontan.Fontan术后患者肝纤维化进展速率
Pediatr Cardiol. 2020 Jun;41(5):905-909. doi: 10.1007/s00246-020-02331-0. Epub 2020 Mar 3.
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Fontan-Associated Anatomical Variants and Hepatic Fibrosis.Fontan 相关解剖变异与肝纤维化。
World J Pediatr Congenit Heart Surg. 2021 Mar;12(2):168-172. doi: 10.1177/2150135120969388.
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A composite noninvasive index correlates with liver fibrosis scores in post-Fontan patients: Preliminary findings.一种复合无创指数与Fontan术后患者的肝纤维化评分相关：初步研究结果。
Congenit Heart Dis. 2018 Jan;13(1):38-45. doi: 10.1111/chd.12558. Epub 2017 Dec 1.
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Does liver biopsy accurately measure fibrosis in Fontan-associated liver disease? A comparison of liver biopsy pre-combined heart and liver transplant and liver explant post-transplant.肝活检能否准确测量 Fontan 相关肝病中的纤维化？肝活检与联合心肝移植前和移植后肝移植标本的比较。
Clin Transplant. 2020 Dec;34(12):e14120. doi: 10.1111/ctr.14120. Epub 2020 Nov 1.
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The clinical spectrum of Fontan-associated liver disease: results from a prospective multimodality screening cohort.Fontan 相关肝疾病的临床谱：前瞻性多模态筛查队列的结果。
Eur Heart J. 2019 Apr 1;40(13):1057-1068. doi: 10.1093/eurheartj/ehy620.
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Noninvasive ultrasound technique for assessment of liver fibrosis and cardiac function in Fontan-associated liver disease: diagnosis based on elastography and hepatic vein waveform type.基于超声弹性成像和肝静脉血流频谱类型的无创性超声技术评估 Fontan 相关肝病的肝纤维化和心功能。
J Med Ultrason (2001). 2021 Apr;48(2):235-244. doi: 10.1007/s10396-020-01078-8. Epub 2021 Jan 8.

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Efficacy of Magnetic Resonance Elastography in Fontan-Associated Liver Disease.磁共振弹性成像在Fontan相关肝病中的疗效
JGH Open. 2025 Sep 4;9(9):e70274. doi: 10.1002/jgh3.70274. eCollection 2025 Sep.
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Alcohol use is prevalent among adults with the fontan circulation but does not correlate with liver disease.在接受Fontan循环手术的成年人中，饮酒现象普遍存在，但与肝脏疾病并无关联。
Int J Cardiol Congenit Heart Dis. 2022 Jan 26;7:100339. doi: 10.1016/j.ijcchd.2022.100339. eCollection 2022 Mar.
3
Care Pattern for Fontan-Associated Liver Disease by Academic Pediatric Hepatologists in Canada.加拿大儿科学术肝脏病专家对Fontan相关肝病的护理模式
JPGN Rep. 2022 Jun 21;3(3):e207. doi: 10.1097/PG9.0000000000000207. eCollection 2022 Aug.
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Screening modalities for the diagnosis of Fontan-associated liver disease: evidence from the past for future development.用于诊断Fontan相关肝病的筛查方式：过去的证据对未来发展的启示
Am J Transl Res. 2022 Mar 15;14(3):1433-1453. eCollection 2022.
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Surveillance of Fontan-associated liver disease: current standards and a proposal from the European Society of Paediatric Radiology Abdominal Task Force.法洛四联症相关肝病的监测：现行标准及欧洲儿科放射学会腹部工作组的建议。
Pediatr Radiol. 2021 Dec;51(13):2598-2606. doi: 10.1007/s00247-021-05173-x. Epub 2021 Oct 15.
6
Congestive Hepatopathy.充血性肝病。
Int J Mol Sci. 2020 Dec 10;21(24):9420. doi: 10.3390/ijms21249420.
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Fontan-associated liver disease and hepatocellular carcinoma in adults.成人法乐四联症相关肝疾病和肝细胞癌。
Sci Rep. 2020 Dec 10;10(1):21742. doi: 10.1038/s41598-020-78840-y.
8
Transplant-Amenable Hepatocellular Carcinoma in a Fontan Patient.一名接受Fontan手术患者的可移植性肝细胞癌
Case Rep Gastroenterol. 2019 Jun 26;13(2):275-279. doi: 10.1159/000501198. eCollection 2019 May-Aug.

本文引用的文献

1
Liver in congenital heart disease: Implications of the fontan procedure for pediatric and adult liver specialists.先天性心脏病中的肝脏：Fontan手术对儿科和成人肝脏专家的启示
Clin Liver Dis (Hoboken). 2013 Oct 30;2(5):210-214. doi: 10.1002/cld.241. eCollection 2013 Oct.
2
Hepatic Fibrosis Is Universal Following Fontan Operation, and Severity is Associated With Time From Surgery: A Liver Biopsy and Hemodynamic Study.Fontan手术后肝纤维化普遍存在，其严重程度与手术时间相关：一项肝活检和血流动力学研究
J Am Heart Assoc. 2017 Apr 26;6(5):e004809. doi: 10.1161/JAHA.116.004809.
3
Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.用于诊断儿童和成人Fontan患者中Fontan相关肝病的非侵入性检查
Front Cardiovasc Med. 2017 Mar 27;4:15. doi: 10.3389/fcvm.2017.00015. eCollection 2017.
4
Diminished liver microperfusion in Fontan patients: A biexponential DWI study.Fontan 患者肝脏微灌注减少：一项双指数扩散加权成像研究。
PLoS One. 2017 Mar 3;12(3):e0173149. doi: 10.1371/journal.pone.0173149. eCollection 2017.
5
Surveillance for liver complications after the Fontan procedure.Fontan手术后肝脏并发症的监测。
Congenit Heart Dis. 2017 Mar;12(2):124-132. doi: 10.1111/chd.12446. Epub 2017 Jan 31.
6
Liver health in adults with Fontan circulation: A multicenter cross-sectional study.成人体Fontan 循环中的肝脏健康：一项多中心横断面研究。
J Thorac Cardiovasc Surg. 2017 Mar;153(3):656-664. doi: 10.1016/j.jtcvs.2016.10.060. Epub 2016 Nov 12.
7
Prevalence and characterization of fibrosis in surveillance liver biopsies of patients with Fontan circulation.Fontan循环患者肝脏监测活检中纤维化的患病率及特征
Hum Pathol. 2016 Nov;57:106-115. doi: 10.1016/j.humpath.2016.07.006. Epub 2016 Jul 27.
8
Fontan circulation causes early, severe liver damage. Should we offer patients a tailored strategy?Fontan循环会导致早期严重肝损伤。我们应该为患者提供个性化策略吗？
Int J Cardiol. 2016 Apr 15;209:60-5. doi: 10.1016/j.ijcard.2016.02.041. Epub 2016 Feb 3.
9
Fontan-associated liver disease: Implications for heart transplantation.Fontan 相关肝疾病：对心脏移植的影响。
J Heart Lung Transplant. 2016 Jan;35(1):26-33. doi: 10.1016/j.healun.2015.10.015. Epub 2015 Oct 19.
10
Fontan Liver Disease: Review of an Emerging Epidemic and Management Options.法洛四联症相关性肝病：一种新兴流行病及管理方案综述
Curr Treat Options Cardiovasc Med. 2015 Nov;17(11):51. doi: 10.1007/s11936-015-0412-z.

Fontan-associated liver disease: Monitoring progression of liver fibrosis.

作者信息

Diamond Tamir, Ovchinsky Nadia

机构信息

Department of Pediatrics Children's Hospital at Montefiore Bronx NY.

Division of Gastroenterology, Hepatology and Nutrition Children's Hospital at Montefiore Bronx NY.

出版信息

Clin Liver Dis (Hoboken). 2018 Jan 31;11(1):1-5. doi: 10.1002/cld.681. eCollection 2018 Jan.

DOI:10.1002/cld.681
PMID:30992779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6385938/
Abstract
摘要