恩前列素的胃黏膜结合研究：一种强效抗溃疡前列腺素。
Gastric mucosal binding studies with enprostil: a potent anti-ulcer prostaglandin.
作者信息
Woo S K, Roszkowski P, Waterbury L D, Garay G L
出版信息
Prostaglandins. 1986 Aug;32(2):243-57. doi: 10.1016/0090-6980(86)90129-2.
PMID:3099330
Abstract
The potent antiulcer prostaglandin enprostil binds with high affinity to porcine gastric mucosal tissues. This binding is saturable, dissociable and displaceable by compounds with similar structures. Various characteristics of binding such as pH optimum and displacement potencies suggest that enprostil binds to mucosal PGE2 sites. Structure-activity and gastric mucosal binding relationships were also examined.
摘要
强效抗溃疡前列腺素恩前列素与猪胃黏膜组织具有高亲和力结合。这种结合具有饱和性、可解离性且能被结构相似的化合物所取代。结合的各种特性，如最适pH值和取代效力，表明恩前列素与黏膜PGE2位点结合。还研究了构效关系和胃黏膜结合关系。
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