Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil.
作者信息
Vernal Sebastian, Bueno-Filho Roberto, Gomes Ciro Martins, Roselino Ana Maria
机构信息
Divisão de Dermatologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Departamento de Dermatologia, Universidade de Brasília, Brasília, DF, Brasil.
出版信息
Rev Soc Bras Med Trop. 2019 Apr 11;52:e20180172. doi: 10.1590/0037-8682-0172-2018.
INTRODUCTION
American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce.
METHODS
We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of coinfection with both diseases.
RESULTS
Nine patients with leishmaniasis (5 cutaneous, 3 mucocutaneous, 1 disseminated case) exhibited concurrent infection with distinct clinical forms of leprosy. Our diagram-based analysis evidenced a divergent clinico-immunological spectrum for each disease in 8 out of 9 cases.
CONCLUSIONS
The spectrum of ATL-leprosy comorbidity suggests that the host has a specific immune response against each pathogen.
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