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先天性弓形虫病:一种复杂且被忽视疾病的早期诊断挑战

Congenital toxoplasmosis: the challenge of early diagnosis of a complex and neglected disease.

作者信息

Soares Janer Aparecida Silveira, Caldeira Antônio Prates

机构信息

Departamento de Saúde da Mulher e da Criança, Universidade Estadual de Montes Claros, Montes Claros, MG, Brasil.

Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, MG, Brasil.

出版信息

Rev Soc Bras Med Trop. 2019 Apr 11;52:e20180228. doi: 10.1590/0037-8682-0228-2018.

DOI:10.1590/0037-8682-0228-2018
PMID:30994797
Abstract

The objective of this study was to report a case of congenital toxoplasmosis that illustrates the difficulties in diagnosing this disease. The case highlights the lack of prophylactic guidelines and shortcomings in the gestational screening process. It demonstrates the peculiarities of the non-specific clinical picture of the infection acquired during pregnancy and identifies the challenges of ophthalmological and high-sensitivity exams in newborns that are crucial for an early diagnosis. These factors contribute to a delay in early treatment of both the mother and the newborn. The lack of skill and expertise of clinical physicians to manage the disease is also addressed.

摘要

本研究的目的是报告一例先天性弓形虫病病例,以说明诊断该病的困难。该病例凸显了缺乏预防指南以及妊娠筛查过程中的缺陷。它展示了孕期感染非特异性临床表现的特点,并确定了新生儿眼科检查和高灵敏度检查对早期诊断的重要性及挑战。这些因素导致母亲和新生儿的早期治疗延迟。同时也提到了临床医生在管理该疾病方面缺乏技能和专业知识的问题。

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Congenital toxoplasmosis: the challenge of early diagnosis of a complex and neglected disease.先天性弓形虫病:一种复杂且被忽视疾病的早期诊断挑战
Rev Soc Bras Med Trop. 2019 Apr 11;52:e20180228. doi: 10.1590/0037-8682-0228-2018.
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[Prevention of congenital toxoplasmosis].[先天性弓形虫病的预防]
Clin Ter. 1990 Sep 30;134(6):383-92.
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[Congenital toxoplasmosis following infection occurring late in pregnancy].[妊娠晚期感染后的先天性弓形虫病]
Arch Pediatr. 2011 Jul;18(7):758-60. doi: 10.1016/j.arcped.2011.04.006. Epub 2011 May 31.
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Late diagnosis of congenital toxoplasmosis based on serological follow-up: A case report.基于血清学随访的先天性弓形虫病迟发诊断:一例报告
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Congenital toxoplasmosis after a preconceptional or periconceptional maternal infection.先天性弓形虫病在孕前或围孕期母体感染后。
Pediatr Infect Dis J. 2009 Jul;28(7):660-1. doi: 10.1097/INF.0b013e3181966020.
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[Congenital toxoplasmosis: pediatric approach. Consensus report of the Swiss infectious disease pediatricians].[先天性弓形虫病:儿科诊疗方法。瑞士儿科传染病专家共识报告]
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Congenital toxoplasmosis treatment.先天性弓形虫病的治疗。
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[Effect of antenatal spiramycin treatment on the frequency of retinochoroiditis due to congenital toxoplasmosis in a Colombian cohort].[哥伦比亚队列中产前螺旋霉素治疗对先天性弓形虫病所致视网膜脉络膜炎发生率的影响]
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Diagnosis and treatment of congenital toxoplasmosis.先天性弓形虫病的诊断与治疗
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[The significance of the results of serological tests carried out during pregnancy for the prevention and diagnosis of congenital toxoplasmosis].孕期进行血清学检测结果对先天性弓形虫病预防和诊断的意义
Z Kinderheilkd. 1969;105(2):132-41.

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Toxoplasmosis in pregnancy: a neglected bane but a serious threat in Nigeria.妊娠合并弓形虫病:在尼日利亚被忽视的祸根,但却是严重的威胁。
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