Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2011 Feb;15(2):193-8.
Congenital toxoplasmosis is a particular manifestation of Toxoplasma gondii infection, which may present as a mild or severe neonatal disease. This pathology remains a difficult challenge in terms of therapy for the pediatrician and gynecologist. In this article we have set ourselves the objective to provide an overview of the main aspects of the disease, with particular attention to the treatment, based on the information in the literature.
Two kinds of treatment are currently available: prenatal and postnatal. When pregnant women seroconvert, spiramycin is administered in order to prevent the mother-to-child transmission. When the fetal infection is confirmed the association of pyrimethamine and sulfadiazine is prescribed. After birth the specific therapy is based on the administration of pyrimethamine and sulfadiazine. However, to date, there is not strong evidence on the effectiveness of treatment, whether prenatal or postnatal.
The studies undertaken so far have not given satisfactory answers. Double-blind randomized controlled trials would be required, but for obvious ethical reasons they cannot be achieved.
先天性弓形虫病是刚地弓形虫感染的一种特殊表现，可表现为新生儿轻度或重度疾病。儿科医生和妇科医生在治疗方面仍然面临着巨大的挑战。本文旨在根据文献信息，概述该疾病的主要方面，特别关注治疗方法。
目前有两种治疗方法：产前和产后。当孕妇血清学转换时，给予螺旋霉素以预防母婴传播。当胎儿感染得到确认时，联合使用乙胺嘧啶和磺胺嘧啶。出生后，具体的治疗方法基于乙胺嘧啶和磺胺嘧啶的使用。然而，迄今为止，无论是产前还是产后，治疗的有效性都没有强有力的证据支持。
到目前为止，已开展的研究并未给出满意的答案。需要进行双盲随机对照试验，但由于明显的伦理原因，这些试验无法进行。
