Department of Radiology, Mayo Clinic, 200 First St SW, 55905, Rochester, MN, USA.
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Clin Neuroradiol. 2020 Sep;30(3):545-552. doi: 10.1007/s00062-019-00819-8. Epub 2019 Aug 6.
To apply intracranial vessel wall imaging (VWI) to determine changes in vessel wall characteristics between North American moyamoya patients and controls, as well as with standard clinical measures of moyamoya disease severity.
North American moyamoya patients and controls underwent intracranial 3.0 T VWI. Moyamoya patients also underwent digital subtraction angiography (DSA), from which modified Suzuki scores (mSS) were calculated. Lumen and outer vessel wall diameters of the supraclinoid internal carotid arteries (ICAs) and basilar artery on VWI were measured by two readers from which wall thickness was calculated. Controls and moyamoya patients were compared in logistic regression using disease category (moyamoya or none) as the dependent variable and wall thickness, age, gender, and side as the explanatory variables (significance: two-sided p < 0.05). In moyamoya patients, regression was performed with mSS as the dependent variable and wall thickness, age, gender, and side as the explanatory variables. Analyses were repeated for each lumen diameter and outer vessel wall diameter in place of wall thickness.
Patients with moyamoya (n = 23, gender = 3/20 male/female; age = 43 ± 12 years) and controls (n = 23, gender = 3/20 male/female, age = 43 ± 13 years) were included. Moyamoya patients showed a significantly smaller ICA lumen and outer vessel wall diameter compared to controls (p < 0.05) but no significant change in vessel wall thickness. Similarly, ICA lumen and outer vessel wall diameters decreased with increasing mSS (p < 0.05).
Findings suggest decreased ICA lumen and outer vessel wall diameters, but no significant difference in wall thickness, between patients and controls. Lumen and outer vessel wall diameters also decreased with disease severity.
应用颅内血管壁成像（VWI）来确定北美烟雾病患者与对照组之间血管壁特征的变化，以及与烟雾病严重程度的标准临床测量值的变化。
北美烟雾病患者和对照组接受了颅内 3.0T VWI 检查。烟雾病患者还接受了数字减影血管造影（DSA）检查，根据该检查计算出改良 Suzuki 评分（mSS）。两位读者通过 VWI 测量了颈内动脉（ICA）虹吸段和基底动脉的管腔和外血管壁直径，并由此计算出壁厚度。采用逻辑回归将疾病类别（烟雾病或无）作为因变量，将壁厚度、年龄、性别和侧别作为解释变量，对对照组和烟雾病患者进行比较（显著性：双侧 p<0.05）。在烟雾病患者中，以 mSS 为因变量，壁厚度、年龄、性别和侧别为解释变量进行回归。用管腔直径和外血管壁直径分别代替壁厚度，对每个直径进行了类似的回归分析。
纳入了 23 例烟雾病患者（性别=3/20 男/女；年龄=43±12 岁）和 23 例对照组（性别=3/20 男/女，年龄=43±13 岁）。与对照组相比，烟雾病患者的 ICA 管腔和外血管壁直径明显较小（p<0.05），但血管壁厚度无显著差异。同样，ICA 管腔和外血管壁直径随 mSS 的增加而减小（p<0.05）。
研究结果表明，患者与对照组之间的 ICA 管腔和外血管壁直径减小，但壁厚度无显著差异。随着疾病严重程度的增加，管腔和外血管壁直径也会减小。
