凝血酶：驱动固有免疫的油门踏板。
Thrombin: A Gas Pedal Driving Innate Immunity.
机构信息
Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
出版信息
Immunity. 2019 Apr 16;50(4):1024-1026. doi: 10.1016/j.immuni.2019.03.006.
Hemostasis and immunity were long considered entirely separate entities. In this issue of Immunity, Burzynski et al. (2019) find that thrombin, the key enzyme within the coagulation cascade, activates IL-1α, a central pleiotropic pro-inflammatory cytokine, to promote wound healing and platelet production following ectoderm injury.
止血和免疫长期以来被认为是完全独立的实体。在本期《Immunity》中，Burzynski 等人（2019 年）发现凝血级联反应中的关键酶——凝血酶激活白细胞介素 1α（IL-1α），这是一种核心多功能促炎细胞因子，以促进外胚层损伤后的伤口愈合和血小板生成。
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