Department of Immunology, Genentech, Inc., South San Francisco, CA 94080, USA.
J Clin Immunol. 2010 Mar;30(2):185-95. doi: 10.1007/s10875-010-9369-6. Epub 2010 Feb 23.
Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major players in the immune response to foreign pathogens. In addition, the pathogeneses of a number of inflammatory diseases have been linked to uncontrolled expression of these cytokine pathways.
Genetic and biochemical analyses have elucidated the cellular and molecular events triggered by these proteins during an inflammatory response. While significant efforts have been placed on understanding the functions of IL-17A, IL-17F, and IL-17E, the significance of the other family members, IL-17B-D, in inflammation remains to be determined.
This review will focus on the cellular sources, target cell/receptors that are utilized by these cytokines to control pathogenesis, and the therapeutic potential of targeting these pathways to treat inflammatory disorders.
越来越多的证据表明白细胞介素 (IL)-17 细胞因子是针对外来病原体的免疫反应的主要参与者。此外，一些炎症性疾病的发病机制已被证明与这些细胞因子途径的失控表达有关。
遗传和生化分析阐明了这些蛋白质在炎症反应中触发的细胞和分子事件。虽然人们已经做出了很大的努力来理解 IL-17A、IL-17F 和 IL-17E 的功能，但其他家族成员（IL-17B-D）在炎症中的意义仍有待确定。
这篇综述将重点介绍这些细胞因子的细胞来源、靶细胞/受体，以及针对这些途径治疗炎症性疾病的治疗潜力。
