Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63139, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63139, USA.
Immunity. 2019 Apr 16;50(4):941-954. doi: 10.1016/j.immuni.2019.03.007.
Arterial inflammation is a hallmark of atherosclerosis, and appropriate management of this inflammation represents a major unmet therapeutic need for cardiovascular disease patients. Here, we review the diverse contributions of immune cells to atherosclerosis, the mechanisms of immune cell activation in this context, and the cytokine circuits that underlie disease progression. We discuss the recent application of these insights in the form of immunotherapy to treat cardiovascular disease and highlight how studies on the cardiovascular co-morbidity that arises in autoimmunity might reveal additional roles for cytokines in atherosclerosis. Currently, data point to interleukin-1β (IL-1β), tumor necrosis factor (TNF), and IL-17 as cytokines that, at least in some settings, are effective targets to reduce cardiovascular disease progression.
动脉炎症是动脉粥样硬化的一个标志，适当控制这种炎症是心血管疾病患者未满足的主要治疗需求。在这里，我们回顾了免疫细胞对动脉粥样硬化的多种贡献，免疫细胞在这种情况下激活的机制，以及构成疾病进展的细胞因子回路。我们讨论了这些见解最近以免疫疗法的形式应用于治疗心血管疾病的情况，并强调了自身免疫中出现的心血管合并症研究可能如何揭示细胞因子在动脉粥样硬化中的其他作用。目前的数据表明，白细胞介素-1β（IL-1β）、肿瘤坏死因子（TNF）和白细胞介素-17 是细胞因子，至少在某些情况下，是减少心血管疾病进展的有效靶点。
