Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.
BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
Fitoterapia. 2019 Jun;135:44-51. doi: 10.1016/j.fitote.2019.04.001. Epub 2019 Apr 14.
The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. All these compounds were tested for cytotoxicity against K562, MCF-7 and/or and HepG2 tumor cell lines. Only tirucadalenone displayed a mild cytotoxic activity.
乳香树（大戟科）的植物化学研究得到了四个新化合物，包括一种罕见的卡达烯型倍半萜（乳香卡达烯酮）、两种乳香烷三萜、 euphorol L 和 euphorol M，后者被描述为差向异构体混合物，以及一种 euphane 三萜，即 euphorol N，以及 7 种已知化合物。它们的结构和绝对构型是通过分析 1D（1H，J 调制 C）和 2D NMR（HSQC、HMBC 和 NOESY）、高分辨率质谱（HRESIMS）、旋光和 GIAO NMR 位移计算以及 CP3 分析，并与文献报道进行比较来阐明的。所有这些化合物都进行了对 K562、MCF-7 和/或 HepG2 肿瘤细胞系的细胞毒性测试。只有乳香卡达烯酮表现出轻微的细胞毒性活性。
