CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Molecules. 2023 Oct 20;28(20):7202. doi: 10.3390/molecules28207202.
Traditional medicinal plants have been used for decades in folk medicines in the treatment and management of several ailments and diseases including diabetes, pain, ulcers, cancers, and wounds, among others. This study focused on the phytochemical and antidiabetic activity of the commonly used antidiabetic medicinal species in Kenya. Phytochemical profiling of these species revealed flavonoids and terpenoids as the major chemical classes reported which have been linked with strong biological activities against the aforementioned diseases, among others. However, out of the selected twenty-two species, many of the natural product isolation studies have focused on only a few species, as highlighted in the study. All of the examined crude extracts from thirteen antidiabetic species demonstrated strong antidiabetic activities by inhibiting α-glucosidase and α-amylase among other mechanisms, while nine are yet to be evaluated for their antidiabetic activities. Isolated compounds S-Methylcysteine sulfoxide, quercetin, alliuocide G, 2-(3,4-Dihydroxybenzoyl)-2,4,6-trihydroxy-3 (2)-benzofuranone, Luteolin-7--D-glucopyranoside, quercetin, 1,3,11-Trihydroxy-9-(3,5,7-trihydroxy-4-1-benzopyran-7-on-2-yl)-5-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one and [1,3,11-Trihydroxy-9-(3,5,7-trihydroxy-4-1-benzopyran-7-on-2-yl)-5-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one]-4'--D-gluco-pyranoside from have been found to exhibit significant antidiabetic activities. With the huge number of adults living with diabetes in Kenya and the available treatment methods being expensive yet not so effective, this study highlights alternative remedies by documenting the commonly used antidiabetic medicinal plants. Further, the study supports the antidiabetic use of these plants with the existing pharmacological profiles and highlights research study gaps. Therefore, it is urgent to conduct natural products isolation work on the selected antidiabetic species commonly used in Kenya and evaluate their antidiabetic activities, both in vitro and in vivo, to validate their antidiabetic use and come up with new antidiabetic drugs.
传统药用植物在民间医学中被使用了几十年，用于治疗和管理多种疾病和病症，包括糖尿病、疼痛、溃疡、癌症和伤口等。本研究侧重于肯尼亚常用的抗糖尿病药用物种的植物化学和抗糖尿病活性。这些物种的植物化学特征分析表明，黄酮类化合物和萜类化合物是主要的化学类别，这些化合物与针对上述疾病等的强烈生物活性有关。然而，在所选择的二十二种物种中，许多天然产物分离研究仅集中在少数几种物种上，正如研究中所强调的那样。在所检查的十三种抗糖尿病物种的粗提取物中，许多都通过抑制α-葡萄糖苷酶和α-淀粉酶等机制表现出很强的抗糖尿病活性，而其他九种仍有待评估其抗糖尿病活性。从 13 种抗糖尿病物种中分离得到的化合物 S-甲基半胱氨酸亚砜、槲皮素、大蒜素 G、2-(3,4-二羟基苯甲酰基)-2,4,6-三羟基-3(2)-苯并呋喃酮、木犀草素-7-O--D-吡喃葡萄糖苷、槲皮素、1,3,11-三羟基-9-(3,5,7-三羟基-4-1-苯并吡喃-7-酮-2-基)-5-(3,4-二羟基苯基)-5,6,11-六氢-5,6,11-三氧杂萘并 12-酮和[1,3,11-三羟基-9-(3,5,7-三羟基-4-1-苯并吡喃-7-酮-2-基)-5-(3,4-二羟基苯基)-5,6,11-六氢-5,6,11-三氧杂萘并 12-酮]-4'-O--D-吡喃葡萄糖苷已被发现具有显著的抗糖尿病活性。肯尼亚有大量成年人患有糖尿病，现有的治疗方法昂贵且效果不佳，本研究通过记录常用的抗糖尿病药用植物，强调了替代疗法。此外，该研究通过现有的药理学特征支持这些植物的抗糖尿病用途，并强调了研究差距。因此，迫切需要对肯尼亚常用的选定抗糖尿病物种进行天然产物分离工作，并在体外和体内评估它们的抗糖尿病活性，以验证其抗糖尿病用途并开发新的抗糖尿病药物。
