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帕金森病及相关疾病患者吞咽困难的管理

Management of Dysphagia in Patients with Parkinson's Disease and Related Disorders.

作者信息

Umemoto George, Furuya Hirokazu

机构信息

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fukuoka University, Japan.

Department of Neurology, Kochi Medical School, Kochi University, Japan.

出版信息

Intern Med. 2020 Jan 1;59(1):7-14. doi: 10.2169/internalmedicine.2373-18. Epub 2019 Apr 17.

DOI:10.2169/internalmedicine.2373-18
PMID:30996170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6995701/
Abstract

Various methods of rehabilitation for dysphagia have been suggested through the experience of treating stroke patients. Although most of these patients recover their swallowing function in a short period, dysphagia in Parkinson's disease (PD) and Parkinson-related disorder (PRD) degenerates with disease progression. Muscle rigidity and bradykinesia are recognized as causes of swallowing dysfunction, and it is difficult to easily apply the strategies for stroke to the rehabilitation of dysphagia in PD patients. Disease severity, weight loss, drooling, and dementia are important clinical predictors. Silent aspiration is a pathognomonic sign that may lead to aspiration pneumonia. Severe PD patients need routine video fluoroscopy or video endoscopy to adjust their food and liquid consistency. Patients with PRD experience rapid progression of swallowing dysfunction. Nutrition combined with nasogastric tube feeding or percutaneous endoscopic gastrostomy feeding should be considered owing to the increased risk of aspiration and difficulty administrating oral nutrition.

摘要

通过治疗中风患者的经验,人们提出了各种吞咽困难的康复方法。尽管这些患者中的大多数在短期内恢复了吞咽功能,但帕金森病(PD)和帕金森相关疾病(PRD)中的吞咽困难会随着疾病进展而恶化。肌肉僵硬和运动迟缓被认为是吞咽功能障碍的原因,并且难以轻易地将中风的康复策略应用于PD患者的吞咽困难康复。疾病严重程度、体重减轻、流口水和痴呆是重要的临床预测指标。隐性误吸是一种可能导致吸入性肺炎的特征性体征。重度PD患者需要常规的视频荧光吞咽造影检查或视频内镜检查,以调整其食物和液体的黏稠度。PRD患者的吞咽功能障碍进展迅速。由于误吸风险增加和口服营养给药困难,应考虑营养支持联合鼻胃管喂养或经皮内镜下胃造口术喂养。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab49/6995701/12aedbc02642/1349-7235-59-0007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab49/6995701/12aedbc02642/1349-7235-59-0007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab49/6995701/12aedbc02642/1349-7235-59-0007-g001.jpg

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PLoS One. 2018 Jun 6;13(6):e0197608. doi: 10.1371/journal.pone.0197608. eCollection 2018.
2
Hospital-based study on emergency admission of patients with Parkinson's disease.基于医院的帕金森病患者急诊入院研究。
eNeurologicalSci. 2016 Apr 25;4:19-21. doi: 10.1016/j.ensci.2016.04.007. eCollection 2016 Sep.
3
Incorporating oral health into interprofessional care teams for patients with Parkinson's disease.
J Pers Med. 2025 Apr 26;15(5):172. doi: 10.3390/jpm15050172.
4
Validation and Reliability of the Polish Version of the Eating Assessment Tool-10 Questionnaire.波兰版饮食评估工具-10问卷的效度与信度
Nutrients. 2025 Apr 8;17(8):1291. doi: 10.3390/nu17081291.
5
Oral health implications in Parkinson's disease.帕金森病对口腔健康的影响。
NPJ Parkinsons Dis. 2025 Apr 11;11(1):73. doi: 10.1038/s41531-025-00927-y.
6
rTMS improves dysphagia by inhibiting NLRP3 inflammasome activation and caspase-1 dependent pyroptosis in PD mice.重复经颅磁刺激(rTMS)通过抑制帕金森病(PD)小鼠的NLRP3炎性小体激活和半胱天冬酶-1依赖性细胞焦亡来改善吞咽困难。
NPJ Parkinsons Dis. 2024 Aug 15;10(1):156. doi: 10.1038/s41531-024-00775-2.
7
Tongue Acupuncture to Treat Dysphagia in Patients with Parkinson's Disease: A Randomized Controlled Trial.舌针治疗帕金森病患者吞咽困难:一项随机对照试验。
Med Acupunct. 2024 Jun 21;36(3):137-145. doi: 10.1089/acu.2023.0073. eCollection 2024 Jun.
8
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9
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10
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Parkinsonism Relat Disord. 2017 Oct;43:9-14. doi: 10.1016/j.parkreldis.2017.07.012. Epub 2017 Jul 17.
4
Effect of an impaired oral stage on swallowing in patients with Parkinson's disease.口腔期受损对帕金森病患者吞咽功能的影响。
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5
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Dysphagia. 2016 Feb;31(1):24-32. doi: 10.1007/s00455-015-9671-9. Epub 2015 Nov 21.
6
Dysphagia Management in Acute and Sub-acute Stroke.急性和亚急性卒中的吞咽障碍管理
Curr Phys Med Rehabil Rep. 2014 Dec 1;2(4):197-206. doi: 10.1007/s40141-014-0061-2.
7
Clinical features and autonomic testing predict survival in multiple system atrophy.临床特征和自主神经检测可预测多系统萎缩的生存率。
Brain. 2015 Dec;138(Pt 12):3623-31. doi: 10.1093/brain/awv274. Epub 2015 Sep 13.
8
Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial.急性脑卒中后使用抗生素预防吞咽困难患者肺炎(STROKE-INF):一项前瞻性、整群随机、开放标签、盲终点、对照临床试验。
Lancet. 2015 Nov 7;386(10006):1835-44. doi: 10.1016/S0140-6736(15)00126-9. Epub 2015 Sep 3.
9
Impact of Aspiration Pneumonia on the Clinical Course of Progressive Supranuclear Palsy: A Retrospective Cohort Study.吸入性肺炎对进行性核上性麻痹临床病程的影响:一项回顾性队列研究
PLoS One. 2015 Aug 13;10(8):e0135823. doi: 10.1371/journal.pone.0135823. eCollection 2015.
10
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Int J Lang Commun Disord. 2015 Sep-Oct;50(5):659-64. doi: 10.1111/1460-6984.12158. Epub 2015 Feb 4.