School of Science, Dalian Maritime University, Dalian, Liaoning, 116026, P. R. China.
Center for Infection and immunity, Columbia University, New York City, New York, USA.
Sci Rep. 2019 Apr 17;9(1):6220. doi: 10.1038/s41598-019-42485-3.
With the rapid growth of the aging population, exploring the biological basis of aging and related molecular mechanisms has become an important topic in modern scientific research. Aging can cause multiple organ function attenuations, leading to the occurrence and development of various age-related metabolic, nervous system, and cardiovascular diseases. In addition, aging is closely related to the occurrence and development of tumors. Although a number of studies have used various mouse models to study aging, further research is needed to associate mouse and human aging at the molecular level. In this paper, we systematically assessed the relationship between human and mouse aging by comparing multi-tissue age-related gene expression sets. We compared 18 human and mouse tissues, and found 9 significantly correlated tissue pairs. Functional analysis also revealed some terms related to aging in human and mouse. And we performed a crosswise comparison of homologous age-related genes with 18 tissues in human and mouse respectively, and found that human Brain_Cortex was significantly correlated with Brain_Hippocampus, which was also found in mouse. In addition, we focused on comparing four brain-related tissues in human and mouse, and found a gene-GFAP-related to aging in both human and mouse.
随着人口老龄化的快速增长，探索衰老的生物学基础和相关的分子机制已成为现代科学研究的重要课题。衰老是多种器官功能衰减的原因，可导致各种与年龄相关的代谢、神经系统和心血管疾病的发生和发展。此外，衰老与肿瘤的发生和发展密切相关。尽管许多研究已经使用各种小鼠模型来研究衰老，但仍需要进一步研究将小鼠和人类衰老在分子水平上联系起来。在本文中，我们通过比较多组织与年龄相关的基因表达谱，系统地评估了人类和小鼠之间的衰老关系。我们比较了 18 个人类和小鼠组织，发现了 9 对显著相关的组织对。功能分析还揭示了人类和小鼠中与衰老相关的一些术语。我们还分别对人类和小鼠的 18 种组织进行了同源性与年龄相关的基因的横向比较，发现人类的 Brain_Cortex 与小鼠的 Brain_Hippocampus 显著相关。此外，我们还重点比较了人类和小鼠的四个与大脑相关的组织，发现了一个与人类和小鼠衰老相关的基因-GFAP。
