Zhang Shu, Wang Qiaoxuan, Zhou Chengjing, Chen Kai, Chang Hui, Xiao Weiwei, Gao Yuanhong
Department of Radiation Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Chin J Cancer Res. 2019 Feb;31(1):212-222. doi: 10.21147/j.issn.1000-9604.2019.01.16.
Colorectal cancer is closely related to inflammation and immune response. Radiotherapy, as a major treatment for colorectal cancer, plays a central role in cancer control. Inflammation caused by ionizing radiation can exert either anti- or pro-tumorigenic effects. Additionally, radiotherapy can elicit an anti-tumor response not only in radiation of target lesions but also in radiation of remote lesions. However, the immune mechanism underlying this effect has not been thoroughly elucidated yet. The combination therapeutic regimen of radiotherapy with other therapeutic methods, including chemotherapy and immunotherapy, has been applied in clinical practice. Meanwhile, radiation toxicity and radiosensitivity have long been problems that affect a patient's quality of life and morbidity. Researchers have found that the abovementioned problems are closely associated with gut microbiota. Here we discuss the impact of immune response induced by radiotherapy on tumor regression and the impact of intestinal flora on the consequent clinical efficacy.
结直肠癌与炎症和免疫反应密切相关。放射治疗作为结直肠癌的主要治疗方法，在癌症控制中起着核心作用。电离辐射引起的炎症可产生抗肿瘤或促肿瘤作用。此外，放射治疗不仅可在靶病变放疗中引发抗肿瘤反应，还可在远隔病变放疗中引发抗肿瘤反应。然而，这种效应背后的免疫机制尚未完全阐明。放射治疗与其他治疗方法（包括化疗和免疫治疗）的联合治疗方案已应用于临床实践。同时，放射毒性和放射敏感性长期以来一直是影响患者生活质量和发病率的问题。研究人员发现，上述问题与肠道微生物群密切相关。在此，我们讨论放疗诱导的免疫反应对肿瘤消退的影响以及肠道菌群对后续临床疗效的影响。
