Palkovsky Martin, Modrackova Nikol, Neuzil-Bunesova Vera, Liberko Marian, Soumarova Renata
Department of Oncology, University Hospital Kralovske Vinohrady, Prague, Czech Republic;
Charles University, Third Faculty of Medicine, Department of Oncology, Prague, Czech Republic.
In Vivo. 2025 Jan-Feb;39(1):37-54. doi: 10.21873/invivo.13803.
Microbiome and radiotherapy represent bidirectionally interacting entities. The human microbiome has emerged as a pivotal modulator of the efficacy and toxicity of radiotherapy; however, a reciprocal effect of radiotherapy on microbiome composition alterations has also been observed. This review explores the relationship between the microbiome and extracranial solid tumors, particularly focusing on the bidirectional impact of radiotherapy on organ-specific microbiome. This article aims to provide a systematic review on the radiotherapy-induced microbial alteration in-field as well as in distant microbiomes. In this review, particular focus is directed to the oral and gut microbiome, its role in the development and progression of cancer, and how it is altered throughout radiotherapy. This review concludes with recommendations for future research, such as exploring microbiome modification to optimize radiotherapy-induced toxicities or enhance its anti-cancer effects.
微生物组与放射治疗是双向相互作用的实体。人类微生物组已成为放射治疗疗效和毒性的关键调节因子；然而，也观察到放射治疗对微生物组组成改变的反向作用。本综述探讨了微生物组与颅外实体瘤之间的关系，特别关注放射治疗对器官特异性微生物组的双向影响。本文旨在对放射治疗引起的局部及远处微生物组变化进行系统综述。在本综述中，特别关注口腔和肠道微生物组、其在癌症发生和发展中的作用，以及在整个放射治疗过程中是如何变化的。本综述最后提出了未来研究的建议，例如探索对微生物组进行调控以优化放射治疗引起的毒性或增强其抗癌效果。
