Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology, Medical University Innsbruck, Innsbruck, Austria.
Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology, Medical University Innsbruck, Innsbruck, Austria.
Cancer Cell. 2018 Jun 11;33(6):954-964. doi: 10.1016/j.ccell.2018.03.004. Epub 2018 Apr 12.
Experimental evidence from the past years highlights a key role for the intestinal microbiota in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on microbial composition and provides risk for developing colorectal carcinoma (CRC). Large metagenomic studies in human CRC associated microbiome signatures with the colorectal adenoma-carcinoma sequence, suggesting a fundamental role of the intestinal microbiota in the evolution of gastrointestinal malignancy. Basic science established a critical function for the intestinal microbiota in promoting tumorigenesis. Further studies are needed to decipher the mechanisms of tumor promotion and microbial co-evolution in CRC, which may be exploited therapeutically in the future.
近年来的实验证据强调了肠道微生物群在炎症性和恶性胃肠道疾病中的关键作用。饮食对微生物组成有很大的影响，并为结直肠癌（CRC）的发展提供了风险。在人类 CRC 相关微生物组特征与结直肠腺瘤-癌序列相关的大型宏基因组研究中，提示肠道微生物群在胃肠道恶性肿瘤的演变中起着根本作用。基础科学已经确定了肠道微生物群在促进肿瘤发生中的关键作用。需要进一步的研究来阐明 CRC 中肿瘤促进和微生物共同进化的机制，这可能在未来被用于治疗。
