Houston Methodist Cancer Center/Weill Cornell Medicine, Outpatient Tower, Floor 24, 6445 Main Street, Houston, TX, 77030, USA.
Curr Oncol Rep. 2019 Apr 17;21(6):51. doi: 10.1007/s11912-019-0795-1.
Aromatase inhibitor-induced arthralgia (AIA) is a very common syndrome which significantly affects breast cancer survivors' quality of life, and it often leads to non-compliance with aromatase inhibitor (AI) therapy. However, the treatment of AIA remains a clinical challenge. Here, we will review the current data for acupuncture and vitamin D in the management of AIA.
Acupuncture has been shown to improve AIA symptoms, but it has not consistently been proven to offer significantly more clinical benefit than sham acupuncture. Similarly, while some vitamin D trials have shown benefit, the studies have not consistently shown improvement in AIA symptoms. Neither acupuncture nor vitamin D can be touted as standard treatments for AIA. However, many patients do experience subjective improvement of their symptoms with these therapies. When other treatments, such as exercise and duloxetine, are not feasible or not effective, it is reasonable to offer a trial of acupuncture or vitamin D to patients who are suffering from AIA, as the potential harms are very few, and they do offer possible relief from AIA symptoms.
芳香化酶抑制剂相关关节痛（AIA）是一种常见的综合征，严重影响乳腺癌幸存者的生活质量，且常导致患者不依从芳香化酶抑制剂（AI）治疗。然而，AIA 的治疗仍然是一个临床挑战。本文将综述目前针灸和维生素 D 治疗 AIA 的相关数据。
针灸可改善 AIA 症状，但与假针灸相比，并不总能显著提供更多的临床获益。同样，虽然一些维生素 D 试验显示有效，但这些研究并未一致显示 AIA 症状改善。针灸和维生素 D 都不能被吹捧为 AIA 的标准治疗方法。然而，许多患者确实会主观感受到这些治疗方法对其症状的改善。当其他治疗方法（如运动和度洛西汀）不可行或无效时，对于患有 AIA 的患者，尝试针灸或维生素 D 是合理的，因为潜在危害很小，且它们确实可以缓解 AIA 症状。
