尼日利亚某养牛场锥虫属对乙酰氨基阿苯达唑疑似耐药情况。
Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria.
作者信息
Odeniran Paul Olalekan, Macleod Ewan Thomas, Ademola Isaiah Oluwafemi, Welburn Susan Christina
机构信息
Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria, Ibadan, Nigeria.
Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, EH8 9YL, UK.
出版信息
Trop Anim Health Prod. 2019 Sep;51(7):2091-2094. doi: 10.1007/s11250-019-01902-5. Epub 2019 Apr 17.
African animal trypanosomiasis is a major cause of mortality and economic losses for the livestock industry in Nigeria. Chemotherapy has been the most reliable option for cattle herders, and the most commonly found drug on the market is diminazene aceturate. To ascertain the long-term efficacy of this compound, we sampled a cattle herd in Ogun State, Nigeria, 2 months after they were treated with diminazene aceturate. The ITS-PCR results revealed 19 positives for trypanosome DNA out of the 79 samples tested (24.1%, 95% CI 16.0-34.5). Seventeen out of the total 19 positives were Trypanosoma congolense (21.5%, 95% CI 13.9-31.8). Mixed infections were also observed. Therefore, the persistence of bovine trypanosomiasis at this Nigerian cattle farm despite treatment could be due to diminazene aceturate resistant trypanosomes being present in the herd.
非洲动物锥虫病是尼日利亚畜牧业死亡和经济损失的主要原因。化疗一直是牧民最可靠的选择，市场上最常见的药物是乙酰氨基阿苯达唑。为了确定该化合物的长期疗效，我们在尼日利亚奥贡州的一个牛群用乙酰氨基阿苯达唑治疗2个月后对其进行了采样。ITS-PCR结果显示，在79个测试样本中，有19个锥虫DNA呈阳性（24.1%，95%可信区间16.0 - 34.5）。19个阳性样本中有17个是刚果锥虫（21.5%，95%可信区间13.9 - 31.8）。还观察到混合感染。因此，尽管进行了治疗，但该尼日利亚养牛场的牛锥虫病持续存在可能是由于牛群中存在对乙酰氨基阿苯达唑耐药的锥虫。
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