Maltais M, de Souto Barreto P, Rolland Y, Vellas B
Mathieu Maltais, PhD, Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment B, 37 Allée Jules Guesde, 31000, Toulouse France, +33 6 74 70 63 71, E-mail :
J Frailty Aging. 2019;8(2):62-66. doi: 10.14283/jfa.2019.7.
BACKGROUND/OBJECTIVES: Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer's Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults.
Longitudinal observational study using data from a randomized controlled trial.
Community-dwelling older adults.
1300 older adults (≥70 years old) with ApoE ε4 status from the Multidomain Alzheimer's Preventive Trial (MAPT) were followed for three years.
Lower-limb function was measured with the Short Physical Performance Battery (SPPB) and muscle strength was measured with a handgrip strength dynamometer. ApoE ε4 status was assessed with a blood draw. Mixed-effect linear regressions were used to examine cross-sectional as well as prospective associations between ApoE ε4 status and the outcomes.
No significant cross-sectional or prospective associations were found between ApoE ε4 status, lower-limb function and handgrip strength in our study.
ApoE ε4 status was not associated with motor function in older adults.
背景/目的：载脂蛋白（ApoE ε4）状态与多种心血管疾病和阿尔茨海默病相关。一些研究发现，在健康老年人中，ApoE ε4等位基因的存在与运动功能下降之间可能存在关联。本研究的目的是测量ApoE ε4状态与老年人下肢功能和握力之间的横断面和前瞻性关联。
使用来自一项随机对照试验的数据进行纵向观察性研究。
社区居住的老年人。
来自多领域阿尔茨海默病预防试验（MAPT）的1300名≥70岁且具有ApoE ε4状态的老年人被随访了三年。
使用简短体能状况量表（SPPB）测量下肢功能，使用握力计测量肌肉力量。通过抽血评估ApoE ε4状态。采用混合效应线性回归来检验ApoE ε4状态与结果之间的横断面和前瞻性关联。
在我们的研究中，未发现ApoE ε4状态、下肢功能和握力之间存在显著的横断面或前瞻性关联。
ApoE ε4状态与老年人的运动功能无关。
