Lertjirachai Itsara, Stem Maxwell S, Moysidis Stavros N, Koulisis Nicole, Capone Antonio, Drenser Kimberly A, Trese Michael T
Ophthalmic Surg Lasers Imaging Retina. 2019 Apr 1;50(4):215-220. doi: 10.3928/23258160-20190401-03.
To quantify vessel tortuosity among infants with retinopathy of prematurity (ROP).
This was a retrospective study including 61 RetCam images from 33 infants. The laser treatment (LT) group included 17 infants who underwent laser for ROP. The no-treatment (NT) group included 16 infants. The modified ROPtool was used to calculate mean vessel tortuosity (MVT) and highest vessel tortuosity (HVT) for the participants and for the standard plus disease photograph from the Early Treatment for Retinopathy of Prematurity (ETROP) study.
The median MVT was 1.226 versus 1.056 for the LT and NT groups, respectively (P < .001). The median HVT was 1.346 versus 1.088 (P < .001). An MVT of 1.124 was 96.7% sensitive and 100% specific for identifying infants with treatment-requiring ROP. Both MVT and HVT cutoff values correctly captured plus disease in the standard ETROP trial photograph.
The modified ROPtool can be used to identify infants who have treatment-requiring ROP with a high level of sensitivity and specificity. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:215-220.].
量化早产儿视网膜病变（ROP）患儿的血管迂曲度。
这是一项回顾性研究，纳入了33例婴儿的61张RetCam图像。激光治疗（LT）组包括17例接受ROP激光治疗的婴儿。未治疗（NT）组包括16例婴儿。使用改良的ROPtool计算参与者以及早产儿视网膜病变早期治疗（ETROP）研究中的标准加疾病照片的平均血管迂曲度（MVT）和最高血管迂曲度（HVT）。
LT组和NT组的MVT中位数分别为1.226和1.056（P <.001）。HVT中位数分别为1.346和1.088（P <.001）。MVT为1.124时，识别需要治疗的ROP婴儿的敏感性为96.7%，特异性为100%。MVT和HVT临界值均能正确识别ETROP标准试验照片中的附加病变。
改良的ROPtool可用于以高敏感性和特异性识别需要治疗的ROP婴儿。[眼科手术激光成像视网膜。2019；50：215 - 220。]
