纳米级金属有机骨架的层次结构将高 Z 组件结合在一起，用于多种放射性增强。
Nanoscale Metal-Organic Framework Hierarchically Combines High-Z Components for Multifarious Radio-Enhancement.
出版信息
J Am Chem Soc. 2019 May 1;141(17):6859-6863. doi: 10.1021/jacs.9b03029. Epub 2019 Apr 22.
With tunability and porosity, nanoscale metal-organic frameworks (nMOFs) can incorporate multiple components to realize complex functions for biomedical applications. Here we report the synthesis of W@Hf-DBB-Ir, a new nMOF assembly hierarchically incorporating three high-Z components-Hf-based metal-oxo clusters, Ir-based bridging ligands, and W-based polyoxometalates (POMs)-as a multifarious radioenhancer. Cationic Hf-DBB-Ir was built from Hf secondary building units (SBUs) and [Ir(bpy)(ppy)] (bpy = 2,2'-bipyridine, ppy = 2-phenylpyridine) derived dicarboxylate ligands (DBB-Ir) and then loaded with Wells-Dawson-type [PWO] (W) POMs to afford W@Hf-DBB-Ir. Upon X-ray irradiation, W@Hf-DBB-Ir significantly enhances hydroxyl radical generation from Hf SBUs, singlet oxygen generation from DBB-Ir ligands, and superoxide generation from W POMs, respectively. Through synergistic cell killing by these distinct reactive oxygen species, W@Hf-DBB-Ir elicited superb anticancer efficacy with >98% tumor regression at a low X-ray dose of 5 × 1 Gy.
具有可调性和多孔性的纳米尺度金属有机骨架（nMOFs）可以纳入多种成分，以实现用于生物医学应用的复杂功能。在这里，我们报告了 W@Hf-DBB-Ir 的合成，这是一种新的 nMOF 组装体，分层纳入了三种高 Z 成分 - Hf 基金属氧簇、Ir 基桥连配体和 W 基多金属氧酸盐（POMs）- 作为多功能的放射增敏剂。阳离子 Hf-DBB-Ir 由 Hf 次级建筑单元（SBUs）和 [Ir(bpy)(ppy)]（bpy = 2,2'-联吡啶，ppy = 2-苯基吡啶）衍生的二羧酸配体（DBB-Ir）构建，然后负载 Wells-Dawson 型 [PWO]（W）POMs，得到 W@Hf-DBB-Ir。在 X 射线照射下，W@Hf-DBB-Ir 分别显著增强了 Hf SBUs 产生的羟基自由基、DBB-Ir 配体产生的单线态氧和 W POMs 产生的超氧自由基的生成。通过这些不同的活性氧协同杀死细胞，W@Hf-DBB-Ir 在低 X 射线剂量 5×1 Gy 下表现出优异的抗癌功效，肿瘤退缩率超过 98%。
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