Department of Chemistry, The University of Chicago, 929 East 57th street, Chicago, IL, 60637, USA.
Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12102-12106. doi: 10.1002/anie.201704828. Epub 2017 Aug 25.
We report the rational design of metal-organic layers (MOLs) that are built from [Hf O (OH) (HCO ) ] secondary building units (SBUs) and Ir[bpy(ppy) ] - or [Ru(bpy) ] -derived tricarboxylate ligands (Hf-BPY-Ir or Hf-BPY-Ru; bpy=2,2'-bipyridine, ppy=2-phenylpyridine) and their applications in X-ray-induced photodynamic therapy (X-PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X-rays and transfer energy to Ir[bpy(ppy) ] or [Ru(bpy) ] moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X-rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X-PDT to afford superb anticancer efficacy.
我们报告了金属-有机层（MOLs）的合理设计，这些层由[HfO(OH)(HCO3)]次级构建单元（SBUs）和 Ir[bpy(ppy)]-或[Ru(bpy)]-衍生的三羧酸配体（Hf-BPY-Ir 或 Hf-BPY-Ru；bpy=2,2'-联吡啶，ppy=2-苯基吡啶）构建而成，并将其应用于结肠癌的 X 射线诱导光动力治疗（X-PDT）。SBUs 中的重 Hf 原子有效地吸收 X 射线，并将能量传递给 Ir[bpy(ppy)]或[Ru(bpy)]部分，通过产生活性氧物种（ROS）来诱导 PDT。X 射线能够深入穿透组织的能力以及通过超薄二维 MOL（约 1.2nm）有效扩散 ROS，使 X-PDT 具有极高的疗效，从而获得出色的抗癌效果。
