Center for Neural Science, New York University, New York, NY 10003, USA.
Center for Neural Science, New York University, New York, NY 10003, USA.
Neurobiol Learn Mem. 2019 May;161:143-148. doi: 10.1016/j.nlm.2019.04.007. Epub 2019 Apr 15.
The mechanisms of de novo gene expression and translation of specific gene transcripts have long been known to support long-lasting changes in synaptic plasticity and behavioral long-term memory. In recent years, it has become increasingly apparent that gene expression is heavily regulated not only on the level of transcription, but also through post-transcriptional gene regulation, which governs the subcellular localization, stability, and likelihood of translation of mRNAs. Specific families of RNA-binding proteins (RBPs) bind transcripts which contain AU-rich elements (AREs) within their 3' UTR and thereby govern their downstream fate. These post-transcriptional gene regulatory mechanisms are coordinated through the same cell signaling pathways that play critical roles in long-term memory formation. In this review, we discuss recent results that demonstrate the roles that these ARE-binding proteins play in LTM formation.
新基因表达和特定基因转录本翻译的机制长期以来一直被认为支持突触可塑性和行为性长期记忆的持久变化。近年来，越来越明显的是，基因表达不仅受到转录水平的严格调控，而且还受到转录后基因调控的调控，转录后基因调控控制着 mRNA 的亚细胞定位、稳定性和翻译的可能性。特定的 RNA 结合蛋白 (RBP) 家族结合含有其 3'UTR 中富含 AU 的元件 (ARE) 的转录本，从而控制其下游命运。这些转录后基因调控机制通过在长时记忆形成中起关键作用的相同细胞信号通路进行协调。在这篇综述中，我们讨论了最近的结果，这些结果表明这些 ARE 结合蛋白在 LTM 形成中的作用。
