Moreau J F, Bonneville M, Godard A, Gascan H, Gruart V, Moore M A, Soulillou J P
C R Acad Sci III. 1987;304(1):5-10.
Alloreactive T-cell clones obtained from cells infiltrating a human rejected kidney graft were shown to produce upon specific antigenic stimulation with interleukin 2, a factor triggering the proliferation of an interleukin 3 dependent murine cell line. The lymphokine responsible for this activity was a monomeric glycoprotein (MW = 41,000) exhibiting on one hand chemotactic as well as activating properties on murine and human eosinophils respectively, and on the other hand a burst promoting activity. Its biochemical and biological features strongly suggest that this factor cannot be likened to any known human lymphokine.
从浸润人类排斥肾移植组织的细胞中获得的同种反应性T细胞克隆，经白细胞介素2特异性抗原刺激后，可产生一种能触发白细胞介素3依赖的鼠细胞系增殖的因子。负责这种活性的淋巴因子是一种单体糖蛋白（分子量=41,000），一方面对鼠和人类嗜酸性粒细胞分别具有趋化和激活特性，另一方面具有促爆发活性。其生化和生物学特性强烈表明，该因子不能与任何已知的人类淋巴因子相类比。
