Tadege Melaku
Department of Statistics, Injibara University, Injibara, Amhara, Ethiopia.
BMC Res Notes. 2019 Apr 18;12(1):232. doi: 10.1186/s13104-019-4267-3.
The aim of this study was to determine the major risk factors of antiretroviral therapy dropout. The retrospective cohort research design was applied. 1512 HIV patients were included from Mettu Karl Hospital in Illubabor Zone, southwest part of Ethiopia from September 2005 to January 2018. Kaplan-Meier comparison and log-logistic regression accelerated failure time model were used.
From the log-logistic regression result, the risk of dropout for patients with primary education status was 10.58% greater as compared to illiterate (p < 0.0110). The probability of dropout for patients with marital status separated was about 16.82% higher than those patients with marital status divorced (p < 0.0070). Being merchant, farmer and daily labour had a greater risk of dropout as compared to a housewife. Most of the HIV/AIDS patients on ART were dropout in a short period due to patients separated marital status, primary education, CD4, being merchants, farmer and daily labour. Investigation on the cause of antiretroviral therapy dropout from a number of AIDS clinics in the country is highly appreciated.
本研究旨在确定抗逆转录病毒治疗中断的主要风险因素。采用回顾性队列研究设计。2005年9月至2018年1月，从埃塞俄比亚西南部伊鲁巴博尔地区的梅图卡尔医院纳入了1512名艾滋病毒患者。使用了Kaplan-Meier比较法和对数逻辑回归加速失效时间模型。
根据对数逻辑回归结果，小学教育程度的患者治疗中断风险比文盲患者高10.58%（p < 0.0110）。分居婚姻状况的患者治疗中断概率比离婚婚姻状况的患者高约16.82%（p < 0.0070）。与家庭主妇相比，从事商业、务农和日工工作的患者治疗中断风险更大。由于婚姻状况分居、小学教育程度、CD4水平、从事商业、务农和日工工作，大多数接受抗逆转录病毒治疗的艾滋病毒/艾滋病患者在短期内中断治疗。对该国多家艾滋病诊所抗逆转录病毒治疗中断原因进行调查非常有必要。
