Tillman J, Leask J T, Campbell J, Logue F C, Fraser W D
Clin Chim Acta. 1986 Dec 15;161(2):233-8. doi: 10.1016/0009-8981(86)90216-0.
We observed that a few patients taking the anti-inflammatory drug fenoprofen showed increases in total and free T3 serum levels without convincing evidence of an associated thyrotoxicosis. To confirm these findings, two volunteers were given fenoprofen for two weeks. Within this time total T3 levels almost doubled and free T3 levels increased threefold. Administration of fenoprofen did not have any measurable effect on T4 or TSH estimations. Cross-reactivities of fenoprofen and 4'-hydroxyfenoprofen were studied with antisera from various total and free T3 assays. Results show that the metabolite cross-reacts with the antisera from Amerlex total and free T3 assay kits. A lesser degree of interference was observed with the Corning total and free T3 assays. 4'-hydroxyfenoprofen had no effect on an 'in house' total T3 assay. Laboratories should therefore be aware of the possibility that their assay may be subject to interference by fenoprofen or its metabolites while clinicians should be aware of this interference in order that they may avoid unnecessary and harmful treatment.
我们观察到，一些服用抗炎药非诺洛芬的患者血清总T3和游离T3水平升高，但没有确凿证据表明存在相关的甲状腺毒症。为了证实这些发现，两名志愿者服用非诺洛芬两周。在此期间，总T3水平几乎翻倍，游离T3水平增加了两倍。非诺洛芬的给药对T4或TSH测定没有任何可测量的影响。用来自各种总T3和游离T3测定的抗血清研究了非诺洛芬和4'-羟基非诺洛芬的交叉反应性。结果表明，该代谢物与Amerlex总T3和游离T3检测试剂盒的抗血清发生交叉反应。康宁总T3和游离T3检测观察到的干扰程度较小。4'-羟基非诺洛芬对“内部”总T3检测没有影响。因此，实验室应意识到其检测可能受到非诺洛芬或其代谢物干扰的可能性，而临床医生应意识到这种干扰，以便避免不必要和有害的治疗。
