Shoenfeld Y, el-Roeiy A, Ben-Yehuda O, Pick A I
Clin Immunol Immunopathol. 1987 Feb;42(2):250-8. doi: 10.1016/0090-1229(87)90012-2.
Sera from 249 patients with monoclonal gammopathies (85 multiple myeloma, 92 benign monoclonal gammopathies, 53 cryoglobulinemia, 19 Waldenström's macroglobulinemia) were examined for the presence of anti-histone activity. Thirty-four sera were found positive. In 12 of these cases the serum monoclonal immunoglobulins were purified and in all, the anti-histone activity appeared to reside in the monoclonal component. None of the patients had symptomatology of lupus despite high titers of anti-histone activity. This study demonstrates an anti-histone activity of monoclonal components of patients with monoclonal gammopathies.
对249例单克隆丙种球蛋白病患者（85例多发性骨髓瘤、92例良性单克隆丙种球蛋白病、53例冷球蛋白血症、19例华氏巨球蛋白血症）的血清进行抗组蛋白活性检测。发现34份血清呈阳性。在其中12例中，血清单克隆免疫球蛋白被纯化，并且在所有病例中，抗组蛋白活性似乎存在于单克隆成分中。尽管抗组蛋白活性滴度很高，但所有患者均无狼疮症状。本研究证明了单克隆丙种球蛋白病患者单克隆成分具有抗组蛋白活性。
