Hansotia P, Gani K, Friedenberg W
Neurology. 1983 Nov;33(11):1411-5. doi: 10.1212/wnl.33.11.1411.
Serum ratios of monoclonal immunoglobulin (Ig) to total protein, monoclonal immunoglobulin to albumin, CSF/serum Ig-albumin index, and CSF to serum monoclonal immunoglobulin were obtained in 21 patients with multiple myeloma and 2 with Waldenström's macroglobulinemia. Twelve patients (3 with CNS complications) showed CSF monoclonal proteins similar to their serum. CSF IgA levels above 10 mg/dl, IgG levels above 25 mg/dl, CSF-serum IgG ratios above 0.0034 and CSF-serum IgA ratios above 0.0051 were seen in patients with neurologic complications. Our preliminary data may signal early CNS involvement in multiple myeloma.
在21例多发性骨髓瘤患者和2例华氏巨球蛋白血症患者中，测定了单克隆免疫球蛋白（Ig）与总蛋白的血清比值、单克隆免疫球蛋白与白蛋白的血清比值、脑脊液/血清Ig-白蛋白指数以及脑脊液与血清单克隆免疫球蛋白的比值。12例患者（3例有中枢神经系统并发症）脑脊液中的单克隆蛋白与其血清中的相似。有神经系统并发症的患者脑脊液IgA水平高于10mg/dl，IgG水平高于25mg/dl，脑脊液-血清IgG比值高于0.0034，脑脊液-血清IgA比值高于0.0051。我们的初步数据可能预示着多发性骨髓瘤患者早期中枢神经系统受累。
