Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Navarra Institute for Health Research (IdISNA), Pamplona, Spain.
Front Immunol. 2019 Apr 3;10:669. doi: 10.3389/fimmu.2019.00669. eCollection 2019.
The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a on recent advances in this area and their prospective potential for cancer treatment.
补体系统代表了先天免疫反应的一个支柱。该系统对于宿主防御病原体至关重要，包含 50 多种可溶性和膜结合蛋白。新出现的证据强调了它在肿瘤进展中的临床相关性及其在转移中的作用，转移是癌症的标志之一。转移的多步骤过程需要获得形成继发性肿瘤所需的有利功能。因此，靶向补体系统的成分不仅可能影响肿瘤的起始，而且可能影响肿瘤扩散的几个关键步骤。这种新的脆弱性可以与克服肿瘤介导的免疫抑制的当前策略同时利用，为转移性疾病的治疗提供实质性的临床益处。在这篇综述中，我们介绍了该领域的最新进展及其在癌症治疗方面的潜在前景。
