Jung Boknam, Li Taiying, Ji Sungyeon, Lee Jungkwan
Department of Applied Biology, Dong-A University, Busan, Korea.
Mycobiology. 2019 Jan 14;47(1):105-111. doi: 10.1080/12298093.2018.1559122. eCollection 2019 Mar.
Many of the fungicides and antibiotics currently available against plant pathogens are of limited use due to the emergence of resistant strains. In this study, we examined the effects of diphenyleneiodonium chloride (DPIC), an inhibitor of the superoxide producing enzyme NADPH oxidase, against fungal and bacterial plant pathogens. We found that DPIC inhibits fungal spore germination and bacterial cell proliferation. In addition, we demonstrated the potent antibacterial activity of DPIC using rice heads infected with the bacterial pathogen which causes bacterial panicle blight (BPB). We found that treatment with DPIC reduced BPB when applied during the initial flowering stage of the rice heads. These results suggest that DPIC could serve as a new and useful antimicrobial agent in agriculture.
由于耐药菌株的出现，目前许多可用于对抗植物病原体的杀菌剂和抗生素的用途有限。在本研究中，我们检测了超氧化物生成酶NADPH氧化酶的抑制剂二苯基碘鎓氯化物（DPIC）对植物真菌和细菌病原体的影响。我们发现DPIC可抑制真菌孢子萌发和细菌细胞增殖。此外，我们利用感染了引起细菌性穗枯病（BPB）的细菌病原体的稻穗，证明了DPIC具有强大的抗菌活性。我们发现，在稻穗始花期施用DPIC可减轻BPB。这些结果表明，DPIC可作为农业中一种新型且有用的抗菌剂。
