Emerg Infect Dis. 2019 May;25(5):883-890. doi: 10.3201/eid2505.171890.
Bacillus cereus is associated with foodborne illnesses characterized by vomiting and diarrhea. Although some B. cereus strains that cause severe extraintestinal infections and nosocomial infections are recognized as serious public health threats in healthcare settings, the genetic backgrounds of B. cereus strains causing such infections remain unknown. By conducting pulsed-field gel electrophoresis and multilocus sequence typing, we found that a novel sequence type (ST), newly registered as ST1420, was the dominant ST isolated from the cases of nosocomial infections that occurred in 3 locations in Japan in 2006, 2013, and 2016. Phylogenetic analysis showed that ST1420 strains belonged to the Cereus III lineage, which is much closer to the Anthracis lineage than to other Cereus lineages. Our results suggest that ST1420 is a prevalent ST in B. cereus strains that have caused recent nosocomial infections in Japan.
蜡样芽胞杆菌与以呕吐和腹泻为特征的食源性疾病有关。虽然一些导致严重肠外感染和医院感染的蜡样芽胞杆菌菌株被认为是医疗环境中严重的公共卫生威胁，但导致这些感染的蜡样芽胞杆菌菌株的遗传背景尚不清楚。通过进行脉冲场凝胶电泳和多位点序列分型，我们发现一种新型序列型（ST），新登记为 ST1420，是 2006 年、2013 年和 2016 年在日本 3 个地点发生的医院感染病例中分离到的优势 ST。系统发育分析表明，ST1420 菌株属于 Cereus III 谱系，与 Anthracis 谱系的关系比与其他 Cereus 谱系的关系更为密切。我们的研究结果表明，ST1420 是导致日本近期医院感染的蜡样芽胞杆菌菌株中流行的 ST。
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