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核心技术专利：CN118964589B侵权必究
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通过配体促进的钌催化 2-氨基苯基酮和 2-氨基苯甲酰胺与胺的脱氢和脱氨偶联反应合成喹唑啉和喹唑啉酮衍生物。

Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines.

机构信息

Department of Chemistry , Marquette University , Milwaukee , Wisconsin 53201-1881 United States.

出版信息

Org Lett. 2019 May 3;21(9):3337-3341. doi: 10.1021/acs.orglett.9b01082. Epub 2019 Apr 19.

DOI:10.1021/acs.orglett.9b01082
PMID:31002524
Abstract

The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.

摘要

原位形成的钌催化体系([Ru]/L)被发现对 2-氨基苯甲酮与胺脱氢偶联反应具有高度选择性，生成喹唑啉产物。2-氨基苯甲酰胺与胺的脱氨偶联反应导致喹唑啉酮产物的高效形成。该催化偶联方法提供了一种有效合成喹唑啉和喹唑啉酮衍生物的方法，无需使用任何反应试剂或形成任何有毒副产物。

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