Zhero S V, Ganina K P
Eksp Onkol. 1986;8(6):57-62.
An optimal morphologic complex of parameters for evaluation of individual sensitivity of heterotransplants to two anti-cancer drugs--5-fluorouracil and ftorafur has been developed on the basis of clinical and experimental material and using 76 gastric malignant tumours, 1320 heterotransplants in diffusion chambers (DC) in vivo which were implanted to 660 animal recipients. A simplified preclinical evaluation method of the individual sensitivity of the human gastric tumour to fluoropyrimidines is recommended based on dynamic level of mitotic activity in DC in vivo heterotransplants.
基于临床和实验材料，并利用76例胃恶性肿瘤、1320个体内扩散室（DC）中的异种移植物（植入660只动物受体），已开发出一种用于评估异种移植物对两种抗癌药物——5-氟尿嘧啶和替加氟的个体敏感性的最佳形态学参数复合体。基于体内DC异种移植物有丝分裂活性的动态水平，推荐一种简化的临床前评估人胃肿瘤对氟嘧啶个体敏感性的方法。
