Institute of Cell Biology and Biophysics, Leibniz University Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
Institute of Cell Biology and Biophysics, Leibniz University Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
Adv Drug Deliv Rev. 2022 Feb;181:114069. doi: 10.1016/j.addr.2021.114069. Epub 2021 Nov 25.
Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.
造血干细胞（HSCs）是所有类型血细胞的终身来源。它们的功能受其直接微环境（骨髓中的 HSC 龛）控制。尽管细胞外基质（ECM）在通过调节龛结构和细胞功能来控制龛中的重要性已被广泛认可，但它仍未被充分探索。在这篇综述中，我们全面概述了 HSC 龛中的 ECM。为此，我们首先简要概述 HSC 龛生物学，然后逐一回顾不同类别的 ECM 分子在龛中的作用，以及它们如何被细胞感知。讨论了基质重塑以及生物物理学在 HSC 龛功能中的新兴重要性。最后，我们回顾了龛中 ECM 现有知识的应用，包括用于 HSC 扩增或靶向分化的人工 HSC 龛以及药物测试。
