Laboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyotanabe, 610-0394, Kyoto, Japan.
Laboratory of Cognitive and Behavioral Neuroscience, Graduate School of Brain Science, Doshisha University, Kyotanabe, 610-0394, Kyoto, Japan.
Neurosci Res. 2020 Apr;153:62-67. doi: 10.1016/j.neures.2019.04.003. Epub 2019 Apr 16.
Operant conditioning of neuronal activity is a core process for better operation of brain-machine interfaces. However, few studies have investigated the role of reinforcement schedules in neuronal operant conditioning, although they are very effective in behavioral operant conditioning. To test the effect of different reinforcement schedules, the authors trained single-neuron activity in the motor cortex using fixed ratio (FR) and variable ratio (VR) schedules in rats. Neuronal firing rates were enhanced in the FR but not in the VR schedule during conditioning, suggesting that the principles of operant conditioning of neuronal activity are different from those of behavioral responses.
操作性条件反射（Operant conditioning）是脑机接口更好运行的核心过程。然而，尽管强化时间表在行为操作性条件反射中非常有效，但很少有研究调查它们在神经元操作性条件反射中的作用。为了测试不同强化时间表的效果，作者在大鼠的运动皮层中使用固定比例（FR）和可变比例（VR）时间表来训练单个神经元的活动。在条件反射期间，神经元的发射率在 FR 中增强，但在 VR 中没有增强，这表明神经元活动的操作性条件反射的原则与行为反应的原则不同。
