State University Of Pará, Brazil.
State University Of Pará, Brazil.
Arch Gerontol Geriatr. 2019 Jul-Aug;83:121-125. doi: 10.1016/j.archger.2019.03.020. Epub 2019 Mar 27.
Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM.
To study the association between sarcopenia and DM in a community-dwelling elderly population of the Amazon region.
Cross-sectional study, performed in Belém, Brazil, with 1078 patients aged above 60 years old from the Viver Mais Project (VMP). The definition of sarcopenia was based in the European Working Group on Sarcopenia in Older People (EWGSOP). Calf circumference >31 cm was considered normal, muscle strength was discriminated by BMI and measured with the hand grip test, and gait speed <0.8 m/s configured low performance. DM was diagnosed when reported by the patient or medical form, use of hypoglycemic medications/insulin and in the presence of fasting glucose >126 mg/dl or glycated hemoglobin (HbA1c) >6.5% on two occasions. Other medical and socio-demographic data were extracted from medical forms.
The frequency of sarcopenia was 9.4%, while DM was present in 36.87% of the patients, and had an increased occurrence in the sarcopenic group. Female sex, advanced age, DM, coronary insufficiency, osteoporosis, body mass index, waist circumference, triglycerides and functionality were associated with sarcopenia. In multivariate analysis, sarcopenia remained strongly associated with DM (OR: 3.208, 95%CI: 1.784-5.769).
This study describes strong and independent association between sarcopenia and DM. To further clarify these findings, broader prospective cohorts are necessary.
研究表明，肌肉减少症与糖尿病（DM）病理生理机制之间存在内在关系。胰岛素和肌肉代谢的变化是糖尿病患者的特征，并且可以相互作用成为肌肉减少症的加速因素。相反，肌肉减少症患者的葡萄糖耐量较低，血清胰岛素水平较高，易患糖尿病。
研究亚马逊地区社区居住的老年人群中肌肉减少症与 DM 之间的关联。
这是一项横断面研究，在巴西贝伦进行，共有来自 Viver Mais 项目（VMP）的 1078 名年龄在 60 岁以上的患者参与。肌肉减少症的定义基于欧洲老年人肌肉减少症工作组（EWGSOP）。小腿围>31cm 被认为是正常的，肌肉力量通过 BMI 区分，并使用握力测试进行测量，而步速<0.8m/s 则表示运动能力较低。当患者或医疗表格报告、使用降血糖药物/胰岛素以及空腹血糖>126mg/dl 或糖化血红蛋白（HbA1c）>6.5%两次时，诊断为糖尿病。从医疗表格中提取其他医疗和社会人口统计学数据。
肌肉减少症的发生率为 9.4%，而糖尿病的发生率为 36.87%，且在肌肉减少症组中更为常见。女性、高龄、糖尿病、冠状动脉供血不足、骨质疏松症、体重指数、腰围、甘油三酯和功能均与肌肉减少症相关。在多变量分析中，肌肉减少症与糖尿病之间仍存在强烈的关联（OR：3.208，95%CI：1.784-5.769）。
本研究描述了肌肉减少症与 DM 之间的强烈和独立的关联。为了进一步阐明这些发现，需要更广泛的前瞻性队列研究。
